乳腺癌与脑膜瘤的关系:1例报告及文献复习。

PubMed ID
发表日期 2001年Oct月

原始出处 日本临床肿瘤学杂志
Japanese journal of clinical oncology
作者 Kubo  M  Fukutomi  T  Akashi-Tanaka  S  Hasegawa  T 

文献标题 乳腺癌与脑膜瘤的关系:1例报告及文献复习。
Association of breast cancer with meningioma: report of a case and review of the literature.

文献摘要

我们报告一例原发性乳腺癌患者并发脑膜瘤。一位53岁女性因ⅡA期乳腺癌接受左侧改良根治术。组织学上,肿瘤主要为导管内癌,淋巴结转移阴性。左侧肿瘤雌激素受体(ER)阴性,孕激素受体(PR)阳性。四年后,常规随访骨显像怀疑颅骨和/或脑转移。病人当时没有任何症状和体征。磁共振成像(MRI)和血管造影显示右侧矢状窦旁肿块可疑脑膜瘤。肿瘤完全切除。组织学检查,该脑瘤为移行型脑膜瘤(脑膜上皮瘤和纤维型),无恶性表现。ER阴性,PR阳性。她目前在初次手术6年后恢复良好。回顾文献重点介绍了乳腺癌和脑膜瘤之间的关系,这表明可能的激素关系。这种联系的知识对于鉴别诊断出现中枢神经系统症状的乳腺癌患者是很重要的。


We report a case of meningioma subsequently developed in a patient with primary breast carcinoma. A 53-year-old woman received a left modified radical mastectomy because of stage IIA breast carcinoma. Histologically, the tumor was a predominantly intraductal carcinoma with negative lymph node metastasis. Estrogen receptor (ER) was negative but progesterone receptor (PR) of the left tumor was positive by immunohistochemistry. Four years later, cranial bone and/or brain metastasis was suspected from a routine follow-up bone scintigram. The patient showed no symptoms or signs at that time. Magnetic resonance imaging (MRI) and angiography revealed that the right parasagittal mass was suspicious of meningioma. A complete tumor removal was performed. On histological examination, this brain tumor was a transitional-type meningioma (meningotheliomatous and fibrous type) without malignant findings. ER was negative but PR was positive also in this tumor. She is currently well 6 years after the initial surgery. A review of the literature is presented with emphasis on the association between breast cancer and meningioma, which indicates a possible hormonal relationship. The knowledge of this association is important in the differential diagnosis of patients with breast cancer who develop central nervous manifestations.


获取全文 10.1093/jjco/hye109