孕酮受体状态对脑膜瘤预后的价值。

PubMed ID
发表日期 2004年Oct月

原始出处 临床病理学杂志
Journal of clinical pathology
作者 Roser  F  Nakamura  M  Bellinzona  M  Rosahl  S K  Ostertag  H  Samii  M 

文献标题 孕酮受体状态对脑膜瘤预后的价值。
The prognostic value of progesterone receptor status in meningiomas.

文献摘要 BACKGROUND

脑膜瘤是众所周知的经常复发,其长期管理仍有争议。以往的研究表明孕酮及其受体在脑膜瘤复发中起一定作用,但这些受体的存在与患者预后的关系尚不清楚。

AIM

回顾性分析孕酮受体(PR)在脑膜瘤中的表达与预后的关系。

METHODS

应用单克隆抗体对188例脑膜瘤进行免疫组化检测。分析了复发(平均随访65个月)、性别、肿瘤组织一致性、部位、血管密度和斑块外观等因素。

RESULTS

公共关系状况显示男性和女性的价值相当。世界卫生组织(WHO)二级和三级肿瘤的受体明显少于良性脑膜瘤。WHOⅠ级完全切除脑膜瘤PR状态与复发率无显著相关性。然而,PR状态和增殖指数的联合应用可以可靠地预测复发。

CONCLUSIONS

结合常规组织学检查,PR状态有助于描述脑膜瘤的生物学行为。只有结合临床和生物学特征才能描述脑膜瘤的行为,预测其复发,并有助于制定更有效的随访策略。


BACKGROUND

Meningiomas are known to recur frequently, and their longterm management remains controversial. Previous studies indicate that progesterone and its receptors can play a role in the recurrence of meningiomas, but the correlation between the presence of these receptors and patients' outcome is unclear.

AIM

To conduct a retrospective analysis to investigate the prognostic relevance of progesterone receptor (PR) expression in meningiomas.

METHODS

Five hundred and eighty eight meningiomas operated on over a period of 10 years were examined immunohistochemically to determine the PR status using monoclonal antibodies. Several factors including recurrence (mean follow up of 65 month), sex, tumour tissue consistency, location, vascularity, and en plaque appearance were analysed.

RESULTS

PR status showed comparable values for men and women. World Health Organisation (WHO) grade II and III tumours had significantly fewer receptors than benign meningiomas. There was no significant correlation between PR status and recurrence rates in WHO grade I totally removed meningiomas. However, a combination of PR status and proliferation indices was shown to predict recurrence reliably.

CONCLUSIONS

Together with routine histological evaluation, PR status can help to describe the biological behaviour of meningiomas. Only a combination of clinical and biological features can describe the behaviour of meningiomas, predict their recurrence, and help to devise more effective follow up strategies.


获取全文 10.1136/jcp.2004.018333