[用201Tl氯化物和99mTc-MIBI同时进行双同位素SPECT评估脑肿瘤]。

PubMed ID
发表日期 2004年Oct月

原始出处 没有新纪元。神经外科
No shinkei geka. Neurological surgery
作者 Nagai  Hidemasa  Yamasaki  Toshiki  Yamamoto  Yoshiaki  Takada  Daikei  Miyazaki  Takeshi  Sugimoto  Keiji  Matsumoto  Yoshifumi  Akiyama  Yasuhiko  Moritake  Kouzo 

文献标题 [用201Tl氯化物和99mTc-MIBI同时进行双同位素SPECT评估脑肿瘤]。
[Evaluation of brain tumors by simultaneous dual isotope SPECT with 201Tl-chloride and 99mTc-MIBI].

文献摘要

单光子发射计算机断层扫描(SPECT)是检测脑肿瘤的有效手段。在这项研究中,我们评估了201Tl氯化物(Tl)和99mTc MIBI(MIBI)同时双SPECT对脑肿瘤的诊断价值。我们评估了20例,其中胶质母细胞瘤2例,间变性星形细胞瘤7例,少突胶质瘤2例,间变性室管膜瘤2例,髓母细胞瘤2例,脑膜瘤2例,恶性脑膜瘤1例,垂体腺瘤1例,颅咽管瘤1例。我们分析了感兴趣区域最大计数/像素比下Tl和MIBI中示踪剂的摄取率(T/N比)。早期和延迟图像中的T/N比值分别被描述为早期比值(ER)和延迟比值(DR)。以DR/ER比值计算保留指数(RI)。Tl(DR=0.797*ER+0.359,r=0.871)和MIBI(DR=0.961*ER-0.191,r=0.784)的ER和DR之间存在显著相关性。接下来,我们分析了Tl和MIBI SPECT之间的相关性,包括ER、DR和RI。两者ER值呈强相关(r=0.791),DR值呈弱相关(r=0.556),RI值无相关性(r=0.328)。两者肿瘤体积与T/N比值无相关性(ER-Tl;r=0.0095,DR-TI;r=0.0050,ER-MIBI;r=0.036,DR-MIBI;r=0.254)。最后,RI-Tl和RI-MIBI之间没有相关性(r=0.328)。本文讨论了两种示踪剂的聚集机制的差异,以及同时应用双SPECT对垂体瘤的鉴别诊断、少突胶质细胞瘤的再生和化疗的多药耐药的意义。双SPECT结合Tl和MIBI对脑肿瘤的诊断有一定的价值。


Single photon emission computed tomography (SPECT) is useful for detecting brain tumors. In this study, we evaluated the utility of simultaneous dual SPECT with 201Tl-Chloride (Tl) and 99mTc-MIBI (MIBI) for diagnosis of brain tumors. We evaluated 20 cases, including 2 glioblastomas, 7 anaplastic astrocytomas, 2 oligodendrogliomas, 2 anaplastic ependymomas, 2 medulloblastomas, 2 meningiomas, 1 malignant meningioma, 1 pituitary adenoma, and 1 craniopharyngioma. We analyzed the uptake ratio (T/N ratio) of tracers in both Tl and MIBI at max counts/pixels ratio in the region of interest. The T/N ratios in early and delayed images were described as early ratios (ER) and delay ratios (DR), respectively. The retention index (RI) was calculated as the DR/ER ratio. Significant correlations were found between ER and DR for both Tl (DR = 0.797 * ER + 0.359, r = 0.871), and MIBI (DR = 0.961 * ER - 0.191, r = 0.784). Next, we analyzed the correlations between Tl and MIBI SPECT, for ER, DR, and RI. ER values for the two were strongly correlated (r = 0.791), DR values were weakly correlated (r = 0.556), and RI exhibited no correlation between them (r = 0.328). There were no correlations between tumor volume and T/N ratio for the two (ER-Tl; r = 0.0095, DR-TI; r = 0.0050, ER-MIBI; r = 0.036, DR-MIBI; r = 0.254). Lastly no correlation was found between RI-Tl and RI-MIBI (r = 0.328). We discuss the difference in the mechanism of accumulation of two tracers and the significance of simultaneous dual SPECT using them for the differential diagnosis of pituitary tumors, regrowth of oligodendrogliomas, and multidrug resistance of chemotherapy. Dual SPECT with Tl and MIBI appears to be useful for the diagnosis of brain tumor.