坦索罗辛与哌唑嗪对排尿困难妇女临床和尿动力学参数的影响:一项随机临床试验。

PubMed ID
发表日期 2011年Jan月

原始出处 国际普通医学杂志
International journal of general medicine
作者 Hajebrahimi  Sakineh  Asrbadr  Yadollah Ahmadi  Azaripour  Arash  Sadeghi-Bazargani  Homayoun 

文献标题 坦索罗辛与哌唑嗪对排尿困难妇女临床和尿动力学参数的影响:一项随机临床试验。
Effect of tamsulosin versus prazosin on clinical and urodynamic parameters in women with voiding difficulty: a randomized clinical trial.

文献摘要 OBJECTIVE

比较坦索罗辛和哌唑嗪对排尿功能障碍妇女临床和尿动力学参数的影响。

METHODS

40名临床诊断为排尿功能障碍的20-65岁女性被随机分为两组,每天服用0.4毫克坦索罗辛或1-2毫克哌唑嗪。治疗初期和三个月后,采用美国泌尿学协会症状评分(AUASS)和尿动力学评估进行症状评估。评估患者满意度并记录严重的药物不良反应。使用Student t检验和Mann-Whitney U检验进行统计分析。

RESULTS

虽然两组的AUASS均有改善,但坦索罗辛组的改善率更高。两组尿动力学参数均有改善,但均未恢复正常。哌唑嗪组的药物副作用比坦索罗辛组更常见。与哌唑嗪组(45%)相比,坦索罗辛组的大多数患者(80%)对其治疗感到满意。

CONCLUSION

坦索罗辛和哌唑嗪均能有效缓解排尿功能障碍女性的症状,改善其尿动力学参数。坦索罗辛可能是首选处方药,因为它的副作用更易控制,患者满意度更高。


OBJECTIVE

To compare the effects of tamsulosin and prazosin on clinical and urodynamic parameters in women with voiding dysfunction.

METHODS

Forty women aged 20-65 years with a clinical diagnosis of voiding dysfunction were blindly randomized to two equal groups for treatment with tamsulosin 0.4 mg or 1-2 mg of prazosin daily. Symptom assessment with the American Urological Association Symptom Score (AUASS) and urodynamic evaluation was performed initially and after three months of treatment. Patient satisfaction was evaluated and severe adverse drug effects recorded. Statistical analysis was carried out using the Student's t-test and Mann-Whitney U test.

RESULTS

Although AUASS improved in both groups, the rate of improvement was larger in the tamsulosin group. Urodynamic parameters improved but did not normalize in both groups. Adverse side effects from medication in the prazosin group were more common than in the tamsulosin group. Most of the patients in the tamsulosin group (80%) were satisfied with their treatment compared with those in the prazosin group (45%).

CONCLUSION

Tamsulosin and prazosin are both effective in palliating symptoms of women with voiding dysfunction and improving their urodynamic parameters. Tamsulosin may be the preferred drug to prescribe because of its more amenable side effect profile and greater patient satisfaction.


获取全文 10.2147/IJGM.S16063