非典型纤维组织细胞瘤伴黏液样基质:一种罕见的脑硬脑膜病变。

PubMed ID
发表日期 1979年Jan月

原始出处 巨蟹座
Cancer
作者 Lam  R M  Colah  S A 

文献标题 非典型纤维组织细胞瘤伴黏液样基质:一种罕见的脑硬脑膜病变。
Atypical fibrous histiocytoma with myxoid stroma: a rare lesion arising from dura mater of the brain.

文献摘要

颅内纤维组织细胞瘤很少见。本报告涉及一名24岁白人男性,有8个月的间歇性视觉障碍病史。开颅术显示左前颅窝底部有一个大的、完全的硬膜内病变,没有软脑膜或脑实质受累。大体和显微镜检查显示,肿瘤的纤维原性部分由梭形肿瘤细胞组成,这些细胞呈条状排列,这是纤维组织细胞瘤的特征。与先前报道的三例累及软脑膜和大脑浅层皮质的“纤维黄瘤”相比,目前的病变明显起源于硬脑膜间充质干细胞。另一个明显的肉眼和显微镜特征是粘液成分的存在,约占整个病变的40%。在之前报道的5例颅内纤维组织细胞病变中,未观察到黏液样成分。由于细胞多形性和极罕见的有丝分裂,我们认为病变最好被指定为非典型纤维组织细胞瘤伴黏液样基质。


Intracranial fibrohistiocytic tumors are rare. This report is concerned with a 24-year-old white male who had an 8 month history of intermittent visual disturbance. Craniotomy revealed a large, completely intradural lesion on the floor of the left anterior cranial fossa without involvement of the leptomeninges or brain parenchyma. Gross and microscopic examination revealed that the fibrogenic portion of the tumor was composed of spindle shaped neoplastic cells arranged in storiform pattern, a hallmark of fibrohistiocytic tumor. In contrast to three previously reported cases of "fibrous xanthomas" involving the leptomeninges and superficial cortex of the brain, the present lesion is clearly originated from mesenchymal stem cell of the dura. The other distinct gross and microscopic feature was the presence of myxoid component which constituted about 40% of the entire lesion. The myxoid component had not been observed in previous 5 reported cases of intracranial fibrohistiocytic lesions. Since there was cellular pleomorphism with extremely rare mitosis, it was felt that the lesion be best designated as atypical fibrous histiocytoma with myxoid stroma.


获取全文 10.1002/1097-0142(197901)43:1<237::aid-cncr2820430135>3.0.co;2-k