杜仲提取物治疗高血压的安全性和有效性的临床试验。

PubMed ID
G H
发表日期 2011年Dec月

原始出处 替代医学综述:临床治疗学杂志
Alternative medicine review : a journal of clinical therapeutic
作者 Greenway  Frank  Liu  Zhijun  Yu  Ying  Gupta  Alok 

文献标题 杜仲提取物治疗高血压的安全性和有效性的临床试验。
A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension.
A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension.

文献摘要 BACKGROUND

杜仲叶和树皮制成的茶是日本饮食的一部分。杜仲是一种草药,通过增加一氧化氮,在不受控制的临床试验中降低大鼠和人类的血压。

OBJECTIVE

进行了一项对照临床试验,以评估杜仲树皮水提取物(标准化为8%松脂醇二-β-D-葡萄糖苷(PG))对人类血压的降低作用。

METHODS

研究1:24名血压在120-160/80-100 mmHg之间的健康成年受试者随机接受杜仲提取物500 mg,每日3次,为期8周。在基线检查和八周后使用24小时自动动态血压监测(24小时ABPM)。研究2:杜仲提取物对异丙肾上腺素刺激的脂肪分解的影响在人脂肪细胞试验中进行评估,以确定杜仲是否是β-肾上腺素能阻滞剂。研究3:30名血压在120-160/80-100 mmHg之间的健康成年受试者被随机分为两组,每天三次服用1克杜仲提取物,连续两周,基线和两周后服用24小时ABPM。

RESULTS

研究1:两组之间没有毒性或血压差异。研究2:0.5%w/v杜仲使异丙肾上腺素刺激的脂解作用从缓冲对照的2.67倍降低到1.4倍(P<0.001)。研究3:杜仲提取物耐受性良好,血压平均下降7.5/3.9mmHg(P<0.008)。

CONCLUSION

标准化杜仲提取物可降低血压,并具有β-肾上腺素能阻断活性。杜仲可能是高血压前期适宜的营养干预。


BACKGROUND

A tea made from Eucommia ulmoides leaves and bark is part of the Japanese diet. Eucommia is an herbal medicine that, by increasing nitric oxide, reduced blood pressure (BP) in rats and humans in an uncontrolled clinical trial.

OBJECTIVE

A controlled clinical trial was conducted to evaluate an aqueous bark extract of Eucommia standardized to eight percent pinoresinol di-beta-D-glucoside (PG) for BP reduction in humans.

METHODS

Study 1: Twenty-four healthy adult subjects with a BP between 120-160/80-100 mmHg were randomized to Eucommia extract 500 mg three times daily for eight weeks. Automatic 24-hour ambulatory blood pressure monitoring (24-h ABPM) was utilized at baseline and after eight weeks. Study 2: The effect of the Eucommia extract on isoproterenol-stimulated lipolysis was evaluated in a human fat cell assay to determine whether Eucommia was a beta-adrenergic blocker. Study 3: Thirty healthy adult subjects with a BP between 120-160/80-100 mmHg were randomized to 1 g Eucommia extract three times daily for two weeks with 24-h ABPM at baseline and after two weeks.

RESULTS

Study 1: There was no toxicity or any difference in BP between the two groups. Study 2: Eucommia at 0.5% w/v reduced isoproterenol-stimulated lipolysis from 2.67 to 1.4 times the buffer control (P<0.001). Study 3: The Eucommia extract was well-tolerated and reduced BP by an average of 7.5/3.9 mmHg (P<0.008).

CONCLUSION

The standardized Eucommia extract reduced BP and has beta-adrenergic blocking activity. Eucommia may be an appropriate nutraceutical intervention for prehypertension.

BACKGROUND

A tea made from Eucommia ulmoides leaves and bark is part of the Japanese diet. Eucommia is an herbal medicine that, by increasing nitric oxide, reduced blood pressure (BP) in rats and humans in an uncontrolled clinical trial.

OBJECTIVE

A controlled clinical trial was conducted to evaluate an aqueous bark extract of Eucommia standardized to eight percent pinoresinol di-beta-D-glucoside (PG) for BP reduction in humans.

METHODS

Study 1: Twenty-four healthy adult subjects with a BP between 120-160/80-100 mmHg were randomized to Eucommia extract 500 mg three times daily for eight weeks. Automatic 24-hour ambulatory blood pressure monitoring (24-h ABPM) was utilized at baseline and after eight weeks. Study 2: The effect of the Eucommia extract on isoproterenol-stimulated lipolysis was evaluated in a human fat cell assay to determine whether Eucommia was a beta-adrenergic blocker. Study 3: Thirty healthy adult subjects with a BP between 120-160/80-100 mmHg were randomized to 1 g Eucommia extract three times daily for two weeks with 24-h ABPM at baseline and after two weeks.

RESULTS

Study 1: There was no toxicity or any difference in BP between the two groups. Study 2: Eucommia at 0.5% w/v reduced isoproterenol-stimulated lipolysis from 2.67 to 1.4 times the buffer control (P <0.001). Study 3: The Eucommia extract was well-tolerated and reduced BP by an average of 7.5/3.9 mmHg (P<0.008).

CONCLUSION

The standardized Eucommia extract reduced BP and has beta-adrenergic blocking activity. Eucommia may be an appropriate nutraceutical intervention for prehypertension.