香菇提取物对长期离心运动的抗氧化和炎症反应的影响。

PubMed ID
发表日期 2013年Apr月

原始出处 生理学和药理学杂志:波兰生理学会的官方杂志
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
作者 Zembron-Lacny  A  Gajewski  M  Naczk  M  Siatkowski  I 

文献标题 香菇提取物对长期离心运动的抗氧化和炎症反应的影响。
Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise.

文献摘要

香菇(香菇属香菇)提取物据说由于含有许多生物活性化合物,如麦角硫苷,因此具有强大的抗氧化、抗炎和再生特性。本研究旨在评估香菇提取物对暴露于运动诱导骨骼肌损伤的健康男性的抗氧化和抗炎活性。受试者在两次单独的运动试验(交叉研究)前10天内摄入香菇提取物(700 mg,每天两次)或安慰剂。运动包括在65%最大摄氧量(0%梯度)下90分钟的跑步和在65%最大摄氧量(10%梯度)下15分钟的偏心期。受试者出现肌酸激酶(峰值461±206 IU/L)和白细胞(峰值9.82 x 103/μL)升高,表明肌肉损伤和炎症。运动改变了血浆IL-6(峰值5.29±0.78 pg/mL)、IL-10(峰值24.75±6.22 pg/mL)和IL-1β(峰值0.54±0.09 pg/mL)水平,但相对于基线水平,并不影响肿瘤坏死因子α(TNF-α)水平。香菇提取物对免疫细胞数量和炎症介质水平没有任何影响,但IL-10除外。香菇提取物后,硫醇氧化还原状态(GSHtotal-2GSSG/GSSG)和niric氧化物(NO)浓度增加,而H2O2和8-异丙醇没有改变。综上所述,香菇提取物对长期离心运动后的炎症标志物没有影响,但通过调节一氧化氮浓度和硫醇氧化还原状态显示出抗氧化活性。


The shiitake (Lentinus edodes) extract is purported to have potent antioxidant, anti-inflammatory and regenerative properties due to presence of many bioactive compounds such as ergothioneine. This study was designed to assess the antioxidant and anti-inflammatory activity of shiitake extract in healthy men exposed to exercise-induced skeletal muscles damage. Subjects ingested shiitake mushroom extract (700 mg, two times per day) or placebo for 10 days prior to two separate exercise trials (crossover study). The exercise session involved 90 min run at 65% VO2max (0% gradient) and 15-min eccentric phase at 65% VO2max (-10% gradient). Subjects experienced creatine kinase (peak 461±206 IU/L) and leukocytes (peak 9.82 x 103/μL) elevations indicating muscle damage and inflammation. Exercise altered plasma IL-6 (peak 5.29±0.78 pg/mL), IL-10 (peak 24.75±6.22 pg/mL) and IL-1β (peak 0.54±0.09 pg/mL) levels but did not affect tumour necrosis factor α (TNF-α) level relative to baseline. Shiitake extract did not demonstrate any effect on immune cells number and inflammatory mediators level, with the exception of IL-10. Thiol redox status (GSHtotal-2GSSG/GSSG) and niric oxide (NO) concentration increased after shiitake extract whereas H2O2 and 8-isoprostanes did not change. In conclusion, shiitake mushroom extract had no effect on markers of inflammation following prolonged eccentric exercise but demonstrated an antioxidant activity through the regulation of nitric oxide concentration and thiol redox status.