杜仲作用机理的研究。基于系统药理学方法。

PubMed ID
G H
发表日期 2014年月

原始出处 民族药理学杂志
Journal of ethnopharmacology
作者 Li  Yan  Han  Chunxiao  Wang  Jinghui  Xiao  Wei  Wang  Zhenzhong  Zhang  Jingxiao  Yang  Yinfeng  Zhang  Shuwei  Ai  Chunzhi 

文献标题 杜仲作用机理的研究。基于系统药理学方法。
Investigation into the mechanism of Eucommia ulmoides Oliv. based on a systems pharmacology approach.
Investigation into the mechanism of Eucommia ulmoides Oliv. based on a systems pharmacology approach.

文献摘要 ETHNOPHARMACOLOGY RELEVANCE

尽管中医药长期以来在维护亚洲和许多其他地方的人们的健康方面发挥着重要作用,但其作用机制对于大多数中医药中使用的植物,如杜仲,仍然是模糊不清的。,一种草药,目前广泛用于帮助调节高血压和免疫系统。但其作用机制尚不清楚。因此,有必要对杜仲的作用机理进行研究。

METHODS

采用了药物相似性评价、口服生物利用度预测、多靶点预测和网络药理学技术相结合的系统药理学方法。

RESULTS

这一综合系统的方法有助于成功地确定41个候选化合物杜仲。而39个潜在靶点被这些成分击中,有助于揭示协同作用机制的系统水平。

CONCLUSIONS

我们的工作成功地解释了杜仲的增效机理。用于治疗高血压和增强免疫力。这些结果不仅为了解杜仲的化学和药理基础提供了新的见解,而且为从中草药中发现药物提供了有效途径。


ETHNOPHARMACOLOGY RELEVANCE

Though Traditional Chinese Medicine (TCM) has long been playing a significant role in the maintenance of health for people in Asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in TCM, such as Eucommia ulmoides Oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. However, its functioning mechanism is still unknown. Thus it is necessary to exploit the mechanism of Eucommia ulmoides Oliv.

METHODS

A systems pharmacology approach combining drug-likeness evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques has been used.

RESULTS

This comprehensive systematic approach helps successfully to identify 41 candidate compounds contained in Eucommia ulmoides Oliv. while 39 potential targets hit by these ingredients and helps to uncover the synergistic mechanism of action on a systematic level.

CONCLUSIONS

Our work successfully explains the mechanism of the efficiency of Eucommia ulmoides Oliv. for the treatment of hypertension and enhancing immune. These results not only provide a new insight for the understanding of the chemical and pharmacological basis of Eucommia ulmoides Oliv., but also provide an efficient way for drug discovery from herbal medicine.

ETHNOPHARMACOLOGY RELEVANCE

Though Traditional Chinese Medicine (TCM) has long been playing a significant role in the maintenance of health for people in Asia as well as many other places, the mechanism of its action still remains ambiguous for most of the plants used in TCM, such as Eucommia ulmoides Oliv., a kind of herb that is widely used to help regulate hypertension and the immune system nowadays. However, its functioning mechanism is still unknown. Thus it is necessary to exploit the mechanism of Eucommia ulmoides Oliv.

METHODS

A systems pharmacology approach combining drug-likeness evaluation, oral bioavailability prediction, multiple drug targets prediction as well as network pharmacology techniques has been used.

RESULTS

This comprehensive systematic approach helps successfully to identify 41 candidate compounds contained in Eucommia ulmoides Oliv. while 39 potential targets hit by these ingredients and helps to uncover the synergistic mechanism of action on a systematic level.

CONCLUSIONS

Our work successfully explains the mechanism of the efficiency of Eucommia ulmoides Oliv. for the treatment of hypertension and enhancing immune. These results not only provide a new insight for the understanding of the chemical and pharmacological basis of Eucommia ulmoides Oliv., but also provide an efficient way for drug discovery from herbal medicine.


获取全文 10.1016/j.jep.2013.10.067