杜仲:民族药理学、植物化学和重要中药药理学。

PubMed ID
发表日期 2014年月

原始出处 民族药理学杂志
Journal of ethnopharmacology
作者 He  Xirui  Wang  Jinhui  Li  Maoxing  Hao  Dingjun  Yang  Yan  Zhang  Chunling  He  Rui  Tao  Rui 

文献标题 杜仲:民族药理学、植物化学和重要中药药理学。
Eucommia ulmoides Oliv.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.

文献摘要 ETHNOPHARMACOLOGICAL RELEVANCE

杜仲(杜仲科),也称为Dù-中弘ò土冲是杜仲属的唯一种。杜仲的叶、茎、皮和雄花在中国、日本、韩国等国传统上被用来治疗许多疾病。本文综述了杜仲的植物学、民族药理学、植物化学、生物活性和毒理学等方面的研究进展,并探讨了杜仲进一步研究的可能趋势。

MATERIALS AND METHODS

杜仲的信息是通过互联网(使用Pub-Med、Elsevier、Baidu-Scholar、Google-Scholar、Medline-Plus、ACS、CNKI和科学网)和当地图书馆的书籍收集的。

RESULTS

从杜仲中分离鉴定出112个化合物,包括主要活性成分木脂素和环烯醚萜。体内外研究表明,杜仲单体化合物和提取物具有广泛的药理作用,特别是在治疗高血压、高脂血症、糖尿病、肥胖、性功能障碍、骨质疏松、阿尔茨海默病、衰老、狼疮样综合征和免疫调节等方面。

CONCLUSIONS

杜仲已被用作传统药物的来源和有益的保健食品。杜仲的植物化学和药理学研究受到广泛关注,其提取物和活性成分不断被分离出来并被证明具有多种作用。需要进一步的毒性和临床研究来建立更详细的粗提物和纯化合物数据,从而为患者提供更方便的制剂。因此,对杜仲的民族药理学、植物化学、生物活性及毒性进行综述,将为杜仲的进一步研究和商业开发提供有益的资料。


ETHNOPHARMACOLOGICAL RELEVANCE

Eucommia ulmoides Oliv. (Family Eucommiaceae), also known as Dù-zhòng (Chinese: ), Tuchong (in Japanese), is the sole species of the genus Eucommia. The leaf, stem, and bark as well as staminate flower of Eucommia ulmoides have been traditionally used to cure many diseases in China, Japan, Korea, among others. The aim of this review is to comprehensively outline the botanical description, ethnopharmacology, phytochemistry, biological activities, and toxicology of Eucommia ulmoides and to discuss possible trends for further study of Eucommia ulmoides.

MATERIALS AND METHODS

Information on Eucommia ulmoides was gathered via the internet (using Pub Med, Elsevier, Baidu Scholar, Google Scholar, Medline Plus, ACS, CNKI, and Web of Science) and from books in local libraries.

RESULTS

One-hundred twelve compounds of Eucommia ulmoides, including the main active constituents, lignans and iridoids, have been isolated and identified. In vitro and in vivo studies indicated that monomer compounds and extracts from Eucommia ulmoides possess wide-ranging pharmacological actions, especially in treating hypertension, hyperlipemia, diabetes, obesity, sexual dysfunction, osteoporosis, Alzheimer's disease, aging, lupus-like syndrome, and immunoregulation.

CONCLUSIONS

Eucommia ulmoides has been used as a source of traditional medicine and as a beneficial health food. Phytochemical and pharmacological studies of Eucommia ulmoides have received much interest, and extracts and active compounds continue to be isolated and proven to exert various effects. Further toxicity and clinical studies are warranted to establish more detailed data on crude extracts and pure compounds, enabling more convenient preparations for patients. Therefore, this review on the ethnopharmacology, phytochemistry, biological activities, and toxicity of Eucommia ulmoides will provide helpful data for further studies as well as the commercial exploitation of this traditional medicine.


获取全文 10.1016/j.jep.2013.11.023