钩藤属植物的药用、植物化学和药理学。

PubMed ID
G H
发表日期 2015年Sep月

原始出处 民族药理学杂志
Journal of ethnopharmacology
作者 Zhang  Qian  Zhao  Jiao Jiao  Xu  Jian  Feng  Feng  Qu  Wei 

文献标题 钩藤属植物的药用、植物化学和药理学。
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria.
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria.

文献摘要 ETHNOPHARMACOLOGICAL RELEVANCE

钩藤属植物隶属于茜草科,主要分布于东南亚、非洲、南美等热带地区。它们的叶子和钩子长期以来被认为具有治愈的能力,并且已经被测试用于治疗哮喘、癌症、肝硬化、糖尿病、高血压、中风和风湿病。本文综述了钩藤属植物的民族药理学、植物化学和药理学等方面的研究进展,以期为钩藤属植物的进一步开发提供理论依据。为了更好地了解这个属,信息立体化学和构效关系的吲哚生物碱也表示。

MATERIAL AND METHODS

本综述的文献研究基于各种数据库搜索(SCIFinder、Science Direct、CNKI、Wiley online library、Spring Link、科学网、PubMed、万方数据、Medalink、Google scholar、ACS、Tropicos、澳大拉西亚草本植物园负责人理事会、纽约植物园、Genes植物园非洲植物数据库、,植物名录(SEINet)和图书馆搜索生物摘要和一些民族药理学的地方书籍。

RESULTS

钩藤属植物有19种,是我国、马来西亚、菲律宾、非洲、东南美洲等地重要的民间药材,曾用于治疗哮喘、风湿、高热、高血压、头痛等疾病,从钩藤中分离出吲哚生物碱、三萜类化合物等200多种,吲哚类生物碱以黄酮类、酚类、苯丙烷类等为特征成分,被认为是治疗高血压、癫痫、抑郁症、帕金森病和阿尔茨海默病的主要有效成分。此外,药代动力学和代谢研究表明,吲哚生物碱有可能在早期被吸收、代谢和排泄。此外,CYP同功酶的特异性抑制可以调节其C-10和C-11的羟基化代谢产物。

CONCLUSION

钩藤属植物药理特性的初步研究为其治疗高血压、哮喘、癌症、糖尿病、风湿病和神经退行性疾病提供了有效的药物。为了保证钩藤属植物在临床应用中的安全性和有效性,研究钩藤属植物的生物活性成分、药理机制和毒性以及吲哚生物碱的立体化学和构效关系显得十分重要。


ETHNOPHARMACOLOGICAL RELEVANCE

The genus Uncaria belongs to the family Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and Southeast America. Their leaves and hooks have long been thought to have healing powers and are already being tested as a treatment for asthma, cancer, cirrhosis, diabetes, hypertension, stroke and rheumatism. The present review aims to provide systematically reorganized information on the ethnopharmacology, phytochemistry and pharmacology of the genus Uncaria to support for further therapeutic potential of this genus. To better understanding this genus, information on the stereo-chemistry and structure-activity relationships in indole alkaloids is also represented.

MATERIAL AND METHODS

The literature study of this review is based on various databases search (SCIFinder, Science Direct, CNKI, Wiley online library, Spring Link, Web of Science, PubMed, Wanfang Data, Medalink, Google scholar, ACS, Tropicos, Council of Heads of Australasian Herbaria, The New York Botanical Garden, African Plants Database at Genera Botanical Garden, The Plant List and SEINet) and library search for Biological Abstract and some local books on ethnopharmacology.

RESULTS

19 species of the genus Uncaria are found to be important folk medicines in China, Malaysia, Phillippines, Africa and Southeast America, etc, and have been served for the treatment of asthma, rheumatism, hyperpyrexia, hypertension and headaches, etc. More than 200 compounds have been isolated from Uncaria, including indole alkaloids, triterpenes, flavonoids, phenols, phenylpropanoids, etc. As characteristic constituents, indole alkaloids have been considered as main efficacy component for hypertension, epilepsy, depressant, Parkinson's disease and Alzheimer's disease. In addition, pharmacokinetic and metabolism investigation reveal that the indole alkaloids are likely to be absorbed, metabolized and excreted at early time points. Moreover, the specific inhibition of CYP isozymes can regulate their hydroxylation metabolites at C-10 and C-11.

CONCLUSION

Preliminary investigations on pharmacological properties of the Uncaria species have enlightened their efficacious remedy for hypertension, asthma, cancer, diabetes, rheumatism and neurodegenerative diseases. To ensure the safety and effectiveness in clinical application, research on bioactive compounds, pharmacological mechanisms and toxicity of the genus Uncaria as well as the stereo-chemistry and structure-activity relationships of indole alkaloids seem very important.

ETHNOPHARMACOLOGICAL RELEVANCE

The genus Uncaria belongs to the family Rubiaceae, which mainly distributed in tropical regions, such as Southeast Asia, Africa and Southeast America. Their leaves and hooks have long been thought to have healing powers and are already being tested as a treatment for asthma, cancer, cirrhosis, diabetes, hypertension, stroke and rheumatism. The present review aims to provide systematically reorganized information on the ethnopharmacology, phytochemistry and pharmacology of the genus Uncaria to support for further therapeutic potential of this genus. To better understanding this genus, information on the stereo-chemistry and structure-activity relationships in indole alkaloids is also represented.

MATERIAL AND METHODS

The literature study of this review is based on various databases search (SCIFinder, Science Direct, CNKI, Wiley online library, Spring Link, Web of Science, PubMed, Wanfang Data, Medalink, Google scholar, ACS, Tropicos, Council of Heads of Australasian Herbaria, The New York Botanical Garden, African Plants Database at Genera Botanical Garden, The Plant List and SEINet) and library search for Biological Abstract and some local books on ethnopharmacology.

RESULTS

19 species of the genus Uncaria are found to be important folk medicines in China, Malaysia, Phillippines, Africa and Southeast America, etc, and have been served for the treatment of asthma, rheumatism, hyperpyrexia, hypertension and headaches, etc. More than 200 compounds have been isolated from Uncaria, including indole alkaloids, triterpenes, flavonoids, phenols, phenylpropanoids, etc. As characteristic constituents, indole alkaloids have been considered as main efficacy component for hypertension, epilepsy, depressant, Parkinson's disease and Alzheimer's disease. In addition, pharmacokinetic and metabolism investigation reveal that the indole alkaloids are likely to be absorbed, metabolized and excreted at early time points. Moreover, the specific inhibition of CYP isozymes can regulate their hydroxylation metabolites at C-10 and C-11.

CONCLUSION

Preliminary investigations on pharmacological properties of the Uncaria species have enlightened their efficacious remedy for hypertension, asthma, cancer, diabetes, rheumatism and neurodegenerative diseases. To ensure the safety and effectiveness in clinical application, research on bioactive compounds, pharmacological mechanisms and toxicity of the genus Uncaria as well as the stereo-chemistry and structure-activity relationships of indole alkaloids seem very important.


获取全文 10.1016/j.jep.2015.06.011