杜仲。木脂素通过影响大鼠系膜细胞P21、P27和Bax的表达抑制血管紧张素Ⅱ刺激的增殖。

PubMed ID
G H
发表日期 2015年月

原始出处 循证辅助和替代医学:eCAM
Evidence-based complementary and alternative medicine : eCAM
作者 Jing  Xian  Huang  Wei-Hua  Tang  Yong-Jun  Wang  Ya-Qin  Li  Hui  Tian  Ying-Ying  Chen  Yao  Zhou  Hong-Hao  Ouyang  Dong-Sheng 

文献标题 杜仲。木脂素通过影响大鼠系膜细胞P21、P27和Bax的表达抑制血管紧张素Ⅱ刺激的增殖。
Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells.
Eucommia ulmoides Oliv. (Du-Zhong) Lignans Inhibit Angiotensin II-Stimulated Proliferation by Affecting P21, P27, and Bax Expression in Rat Mesangial Cells.

文献摘要

杜仲皮是杜仲的干燥树皮。Liu等人(2012年)从杜仲中鉴定出的天然产物包括木脂素、环烯醚萜、黄酮类、多糖、萜类和蛋白质。木脂素是主要的生物活性成分,在我们之前的研究中,木脂素对自发性高血压大鼠的高血压肾损伤具有保护作用,Li等人(2012)。此外,杜仲木脂素还减少了肾脏醛糖还原酶(AR)的过度表达,Li等人(2012)。然而,杜仲木脂素保护作用的病理机制尚不清楚。细胞增殖是高血压肾损伤的重要病理改变,血管紧张素Ⅱ(AngⅡ)表达增加是高血压靶器官损伤的重要因素。血管紧张素II是肾素-血管紧张素系统中的主要有效肽,被认为是高血压肾病发展的关键介质,Rüster和Wolf(2011)。初步结果表明,杜仲木脂素对AngⅡ诱导的大鼠系膜细胞增殖有抑制作用。本文研究了杜仲对AngⅡ诱导的大鼠系膜细胞增殖和凋亡的影响。检测细胞周期相关基因P21和P27以及细胞凋亡相关基因Bax和Bcl-2。


Cortex Eucommiae (Du-zhong) is the dried bark of the Eucommia ulmoides Oliv. The natural products identified from Du-zhong include lignans, iridoids, flavonoids, polysaccharides, terpenes, and proteins, Liu et al. (2012). Lignans, the main bioactive components, were protective against hypertensive renal injury in spontaneous hypertensive rats in our previous study, Li et al. (2012). Moreover, Eucommia lignans also diminished aldose reductase (AR) overexpression in the kidney, Li et al. (2012). However, the pathological mechanism underlying the protective effects of Eucommia lignans remains unknown. Cellular proliferation was reported to contribute to important pathological changes in hypertensive renal injuries, and increased angiotensin II (Ang II) expression was reported to be essential for target-organ damage during hypertension. Ang II is the main effective peptide in the renin-angiotensin system and is considered to be a key mediator in the development of hypertensive nephropathy, Rüster and Wolf (2011). Our preliminary results showed that Eucommia lignans had inhibitory effects on Ang II-induced proliferation of rat mesangial cells. In the present study, we investigated the effects of Eucommia ulmoides on Ang II-induced proliferation and apoptosis of rat mesangial cells. Cell cycle-related genes P21 and P27, and cell apoptosis-related genes Bax and Bcl-2, were determined.

Cortex Eucommiae (Du-zhong) is the dried bark of the Eucommia ulmoides Oliv. The natural products identified from Du-zhong include lignans, iridoids, flavonoids, polysaccharides, terpenes, and proteins, Liu et al. (2012). Lignans, the main bioactive components, were protective against hypertensive renal injury in spontaneous hypertensive rats in our previous study, Li et al. (2012). Moreover, Eucommia lignans also diminished aldose reductase (AR) overexpression in the kidney, Li et al. (2012). However, the pathological mechanism underlying the protective effects of Eucommia lignans remains unknown. Cellular proliferation was reported to contribute to important pathological changes in hypertensive renal injuries, and increased angiotensin II (Ang II) expression was reported to be essential for target-organ damage during hypertension. Ang II is the main effective peptide in the renin-angiotensin system and is considered to be a key mediator in the development of hypertensive nephropathy, Rüster and Wolf (2011). Our preliminary results showed that Eucommia lignans had inhibitory effects on Ang II-induced proliferation of rat mesangial cells. In the present study, we investigated the effects of Eucommia ulmoides on Ang II-induced proliferation and apoptosis of rat mesangial cells. Cell cycle-related genes P21 and P27, and cell apoptosis-related genes Bax and Bcl-2, were determined.


获取全文 10.1155/2015/987973