杜仲叶提取物对自发性高血压大鼠血管功能的恢复作用。

PubMed ID
G H
发表日期 2015年Dec月

原始出处 分子(瑞士巴塞尔)
Molecules (Basel, Switzerland)
作者 Hosoo  Shingo  Koyama  Masahiro  Kato  Mai  Hirata  Tetsuya  Yamaguchi  Yasuyo  Yamasaki  Hiroo  Wada  Atsunori  Wada  Keiji  Nishibe  Sansei  Nakamura  Kozo 

文献标题 杜仲叶提取物对自发性高血压大鼠血管功能的恢复作用。
The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats.
The Restorative Effects of Eucommia ulmoides Oliver Leaf Extract on Vascular Function in Spontaneously Hypertensive Rats.

文献摘要

杜仲。叶是一种传统的中国抗高血压和降糖药。我们研究了慢性杜仲叶提取物(ELE)给药对自发性高血压大鼠(shr)动脉功能和形态学的影响。6周龄雄性shr随意口服5%的ELE,连续7周。评估乙酰胆碱(ACh)诱导的内皮依赖性舒张、硝普钠(SNP)诱导的内皮非依赖性舒张、血浆一氧化氮(NO)水平和中膜厚度。与正常饮食的动物相比,ELE显著改善ACh诱导的shr主动脉内皮依赖性舒张,但不影响SNP诱导的内皮非依赖性舒张。在ELE处理的shr中,血浆NO水平和中膜厚度分别显著升高和降低。因此,长期给予ELE可通过提高血浆NO水平和生物利用度,预防SHR主动脉血管肥大,有效改善血管功能。


Eucommia ulmoides Oliv. leaf is a traditional Chinese antihypertensive and antidiabetic medicine. We examined the effects of chronic Eucommia leaf extract (ELE) administration on artery function and morphology in spontaneously hypertensive rats (SHRs). ELE was orally administered via normal diet ad libitum to six-week-old male SHRs at a concentration of 5% for seven weeks. Acetylcholine (ACh)-induced endothelium-dependent relaxation, sodium nitroprusside (SNP)-induced endothelium-independent relaxation, plasma nitric oxide (NO) levels, and media thickness were assessed. ELE significantly improved ACh-induced aortic endothelium-dependent relaxation but did not affect SNP-induced endothelium-independent relaxation in the SHRs, as compared to the animals receiving normal diet. Plasma NO levels and media thickness were significantly increased and decreased, respectively, in the ELE-treated SHRs. Therefore, long-term ELE administration may effectively improve vascular function by increasing plasma NO levels and bioavailability, and by preventing vascular hypertrophy in the SHR aorta.

Eucommia ulmoides Oliv. leaf is a traditional Chinese antihypertensive and antidiabetic medicine. We examined the effects of chronic Eucommia leaf extract (ELE) administration on artery function and morphology in spontaneously hypertensive rats (SHRs). ELE was orally administered via normal diet ad libitum to six-week-old male SHRs at a concentration of 5% for seven weeks. Acetylcholine (ACh)-induced endothelium-dependent relaxation, sodium nitroprusside (SNP)-induced endothelium-independent relaxation, plasma nitric oxide (NO) levels, and media thickness were assessed. ELE significantly improved ACh-induced aortic endothelium-dependent relaxation but did not affect SNP-induced endothelium-independent relaxation in the SHRs, as compared to the animals receiving normal diet. Plasma NO levels and media thickness were significantly increased and decreased, respectively, in the ELE-treated SHRs. Therefore, long-term ELE administration may effectively improve vascular function by increasing plasma NO levels and bioavailability, and by preventing vascular hypertrophy in the SHR aorta.


获取全文 10.3390/molecules201219826