模拟全颈椎间盘置换设计中指定材料组合对全颈椎模型运动学的影响：有限元分析研究。
PubMed ID  

发表日期  2016年月 


原始出处  生物医学材料与工程 
Biomedical materials and engineering  
作者  Qi Yuxin Lewis Gladius 


文献标题  模拟全颈椎间盘置换设计中指定材料组合对全颈椎模型运动学的影响：有限元分析研究。 
Influence of assigned material combination in a simulated total cervical disc replacement design on kinematics of a model of the full cervical spine: A finite element analysis study.  
Influence of assigned material combination in a simulated total cervical disc replacement design on kinematics of a model of the full cervical spine: A finite element analysis study.  


文献摘要 
BACKGROUND
虽然颈椎全椎间盘置换术（TDR）越来越流行，但在模拟TDR植入时，还没有涉及全脊柱颈椎（C1C7）模型和确定指定TDR设计不同部分的材料对模型生物力学的影响的有限分析（FEA）研究。 OBJECTIVE为了确定给定颈椎TDR设计中指定材料组合对全颈椎模型运动学的影响。 METHODS建立完整颈椎的三维实体模型，得到有限元网格（INT模型），然后用有限元法确定三种临床相关载荷下节段间每个位置的运动范围（ROM）。然后在C5C6（TDR模型）处模拟植入一个概念性终板和可移动插入TDR设计来修改INT模型，并施加6个临床相关的应用载荷。使用了四种不同的TDR模型，它们之间的区别在于分配给终板和移动嵌件的材料。在每一个载荷下，确定了每个节段间位置的主运动，并与使用INT模型时的对应运动进行了比较。 RESULTS将INT模型的ROM结果与文献报道的相关实验结果进行比较，证明了模型的有效性。在TDR模型中，与INT模型中相应结果相对应的主要节段间运动百分率变化绝对值的最小总平均值是当分配给终板和活动嵌件的材料是聚醚醚酮时。 CONCLUSION在一个完整颈椎模型中模拟植入一个概念性终板和可移动插入TDR设计，分配给设计部分的材料组合对模型的运动学产生显著影响。 


BACKGROUND
Although cervical total disc replacement (TDR) is becoming popular, there are no finite analysis (FEA) studies involving a model of the full spine cervical (C1C7) and determination of the influence of materials assigned to different parts of a specified TDR design on biomechanics of the model when TDR implantation is simulated. OBJECTIVETo determine the influence of assigned material combination, for a given cervical TDR design, on the kinematics of a model of the full cervical spine. METHODSA threedimensional solid model of the full cervical spine was constructed, a finite element mesh was obtained (INT Model), after which FEA was used to determine range of motion (ROM) at each of the intersegmental positions under three clinicallyrelevant loadings. INT model was then modified by simulated implantation of a notional endplatesandmobile insert TDR design, at C5C6 (TDR Model), and six clinicallyrelevant applied loadings were applied. Four variants of TDR Model were used, the difference between them being in the materials assigned to the endplates and the mobile insert. Under each of the loadings, principal motions at each of the intersegmental positions were determined and compared to counterpart motions when INT Model was used. RESULTSComparison of ROM results of INT Model with relevant experimental results reported in the literature showed that the model was validated. With TDR Model, the smallest overall mean of the absolute values of the % change in principal intersegmental motions (relative to corresponding results in INT Model) was when the material assigned to both the endplates and the mobile insert was poly(etheretherketone). CONCLUSIONIn a simulated implantation of a notional endplatesandmobileinsert TDR design in a model of the full cervical spine, material combination assigned to the parts of the design exerts a marked influence on the kinematics of the model. 

BACKGROUND
Although cervical total disc replacement (TDR) is becoming popular, there are no finite analysis (FEA) studies involving a model of the full spine cervical (C1C7) and determination of the influence of materials assigned to different parts of a specified TDR design on biomechanics of the model when TDR implantation is simulated. OBJECTIVETo determine the influence of assigned material combination, for a given cervical TDR design, on the kinematics of a model of the full cervical spine. METHODSA threedimensional solid model of the full cervical spine was constructed, a finite element mesh was obtained (INT Model), after which FEA was used to determine range of motion (ROM) at each of the intersegmental positions under three clinicallyrelevant loadings. INT model was then modified by simulated implantation of a notional endplatesandmobile insert TDR design, at C5C6 (TDR Model), and six clinicallyrelevant applied loadings were applied. Four variants of TDR Model were used, the difference between them being in the materials assigned to the endplates and the mobile insert. Under each of the loadings, principal motions at each of the intersegmental positions were determined and compared to counterpart motions when INT Model was used. RESULTSComparison of ROM results of INT Model with relevant experimental results reported in the literature showed that the model was validated. With TDR Model, the smallest overall mean of the absolute values of the % change in principal intersegmental motions (relative to corresponding results in INT Model) was when the material assigned to both the endplates and the mobile insert was poly(etheretherketone). CONCLUSIONIn a simulated implantation of a notional endplatesandmobileinsert TDR design in a model of the full cervical spine, material combination assigned to the parts of the design exerts a marked influence on the kinematics of the model. 



获取全文  10.3233/BME161614 