[天麻钩藤联合用药对天麻素和钩藤碱药代动力学的影响]。

PubMed ID
G H
发表日期 2017年Jul月

原始出处 中国中药杂志
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
作者 Wu  Li-Hong  Hou  Jia  Wang  Jue  Luo  Man  Wang  Li-Min  Wang  Jian-Xin  Li  Yong-Ji  Qin  Jing 

文献标题 [天麻钩藤联合用药对天麻素和钩藤碱药代动力学的影响]。
[Effect of combination of gastrodia and uncaria on pharmacokinetics of gastrodin and rhynchophylline].
[Effect of combination of gastrodia and uncaria on pharmacokinetics of gastrodin and rhynchophylline].

文献摘要

研究天麻钩藤联合用药对天麻素和钩藤碱药代动力学的影响,并测定天麻钩藤联合用药后的药代动力学参数∶9.与钩藤组和天麻组相比,天麻素和钩藤碱的Cmax和AUC均显著升高,钩藤碱的tmax分别降低1.5h和0.25h。tmax的变化导致天麻素和钩藤碱的峰时相差1.25h,两者的峰时相同。钩藤具有较强的抑阳作用,天麻具有滋阴抑阳的平衡作用。结果表明,天麻能发挥钩藤的滋阴抑阴作用,避免了钩藤单一治疗导致的阳虚阴虚。一方面,天麻素的AUC和Cmax升高,可提高天麻素的平均血药浓度,弥补钩藤的早期药效丧失;另一方面,钩藤碱AUC和Cmax的增加可以弥补天麻在体内后期的快速清除。二者合用可提高抗高血压作用,达到阴阳平衡。与单纯增加西药用量相比,具有独特的优势。结果符合中医治疗肝阳上亢型高血压病的原则。总之,本研究对阴阳平衡的药代动力学和中医药的治标治本有很好的解释。


To investigate the effect of the combination of gastrodia and uncaria on the pharmacokinetics of gastrodin and rhynchophylline, and determine their pharmacokinetic parameters after administration of the combination of gastrodia and uncaria at the ratio of 12∶9. Compared with uncaria group or gastrodia group, Cmax and AUC of both gastrodin and rhynchophylline were significantly increased, and tmax was retroceded by 1.5 h for rhynchophylline and 0.25 h for gastrodin. The change of tmax resulted in a 1.25 h difference in the peak time between gastrodin and rhynchophylline , which was the same between them. Uncaria shows a more effect in suppressing hyperactive Yang, while gastrodia has a balancing effect by nourishing Yin and suppressing hyperactive Yang. As a result, gastrodia could exert the effect in nourishing Yin and suppressing effect of uncaria, which could avoid the deficiency of Yang affecting Yin due to mono-treatment of uncaria. On one hand, the enhanced AUC and Cmax of gastrodin could increase the average plasma drug concentration of gastrodin, and remedy the losing effect of uncaria at the early stage; On the other hand, the increased AUC and Cmax of rhynchophylline could make up the quick elimination of gastrodia in vivo at the late stage. Their combination could lead to an increased anti-hypertensive effect with the balance of Yin and Yang. They showed unique advantages compared with simple dosage increase of western medicines. The results were consistent with the principle of TCM treatment for the hypertension due to hyperactivity of the liver Yang. In short, this study gives a good pharmacokinetic explanation of the balance of Yin and Yang and TCM treatment for both symptoms and root cause.

To investigate the effect of the combination of gastrodia and uncaria on the pharmacokinetics of gastrodin and rhynchophylline, and determine their pharmacokinetic parameters after administration of the combination of gastrodia and uncaria at the ratio of 12∶9. Compared with uncaria group or gastrodia group, Cmax and AUC of both gastrodin and rhynchophylline were significantly increased, and tmax was retroceded by 1.5 h for rhynchophylline and 0.25 h for gastrodin. The change of tmax resulted in a 1.25 h difference in the peak time between gastrodin and rhynchophylline , which was the same between them. Uncaria shows a more effect in suppressing hyperactive Yang, while gastrodia has a balancing effect by nourishing Yin and suppressing hyperactive Yang. As a result, gastrodia could exert the effect in nourishing Yin and suppressing effect of uncaria, which could avoid the deficiency of Yang affecting Yin due to mono-treatment of uncaria. On one hand, the enhanced AUC and Cmax of gastrodin could increase the average plasma drug concentration of gastrodin, and remedy the losing effect of uncaria at the early stage; On the other hand, the increased AUC and Cmax of rhynchophylline could make up the quick elimination of gastrodia in vivo at the late stage. Their combination could lead to an increased anti-hypertensive effect with the balance of Yin and Yang. They showed unique advantages compared with simple dosage increase of western medicines. The results were consistent with the principle of TCM treatment for the hypertension due to hyperactivity of the liver Yang. In short, this study gives a good pharmacokinetic explanation of the balance of Yin and Yang and TCM treatment for both symptoms and root cause.


获取全文 10.19540/j.cnki.cjcmm.20170523.011