雄激素和雄激素受体在皮肤和毛囊中的作用。

PubMed ID
G H
发表日期 2018年04月

原始出处 分子与细胞内分泌学
Molecular and cellular endocrinology
作者 Ceruti  Julieta María  Leirós  Gustavo José  Balañá  María Eugenia 

文献标题 雄激素和雄激素受体在皮肤和毛囊中的作用。
Androgens and androgen receptor action in skin and hair follicles.
Androgens and androgen receptor action in skin and hair follicles.

文献摘要

除了性功能外,雄激素在皮肤生理和病理生理中发挥作用。皮肤细胞能够从性腺或肾上腺前体合成最活跃的雄激素,参与皮肤类固醇生成的酶参与正常或病理过程。即使雄激素和雄激素受体(AR)在皮肤疾病中的作用已经被研究了几十年,但它们在皮肤疾病中的分子机制仍不清楚。在这里,我们分析了近年来雄激素和AR在几种皮肤相关疾病中的作用,重点是目前对其在雄激素性脱发(AGA)中的分子机制的认识。本文综述了2 5型α-还原酶、AR共激活因子、毛乳头旁分泌因子(如TGF-β、IGF 1、WNTs和DKK-1)的分子病理生理学,以及AR和Wnt信号之间的相互作用,以期对新的治疗方法有所启示。


Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA). We review the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.

Beyond sexual functions, androgens exert their action in skin physiology and pathophysiology. Skin cells are able to synthesize most active androgens from gonadal or adrenal precursors and the enzymes involved in skin steroidogenesis are implicated both in normal or pathological processes. Even when the role of androgens and androgen receptor (AR) in skin pathologies has been studied for decades, their molecular mechanisms in skin disorders remain largely unknown. Here, we analyze recent studies of androgens and AR roles in several skin-related disorders, focusing in the current understanding of their molecular mechanisms in androgenetic alopecia (AGA). We review the molecular pathophysiology of type 2 5α-reductase, AR coactivators, the paracrine factors deregulated in dermal papillae (such as TGF-β, IGF 1, WNTs and DKK-1) and the crosstalk between AR and Wnt signaling in order to shed some light on new promising treatments.


获取全文 10.1016/j.mce.2017.09.009