BPAid在血管舒张活动中使用的信号机制途径概述。

PubMed ID
G H
发表日期 2017年Dec月

原始出处 药用食品杂志
Journal of medicinal food
作者 Loh  Yean Chun  Tan  Chu Shan  Ch'ng  Yung Sing  Ahmad  Mariam  Ng  Chiew Hoong  Yam  Mun Fei 

文献标题 BPAid在血管舒张活动中使用的信号机制途径概述。
Overview of Signaling Mechanism Pathways Employed by BPAid in Vasodilatory Activity.
Overview of Signaling Mechanism Pathways Employed by BPAid in Vasodilatory Activity.

文献摘要

高血压是著名的“无声杀手”之一,可以攻击任何年龄段的人,由于其多种综合征行为和伴随的疾病而成为当前科学家们的热门话题。在先前的一项研究中,将天麻、钩藤、钩藤等五种中药结合,采用了新的科学中药配方方法。以优化的比例(命名为BPAid)食用哈维尔、葛根、三七和泽泻。本研究的目的是通过体外分离主动脉环试验评估BPAid用于血管舒张作用的机制途径。有趣的是,所有研究的机制都与BPAid的血管舒张活性有关,其中大多数通过一氧化氮/可溶性鸟苷酸环化酶/环磷酸鸟苷(NO/sGC/cGMP)途径发挥作用,其次是前列环素(PGI2)、β2-肾上腺素能和M3受体途径。此外,BPAid似乎通过钾和电压控制的钙通道和三磷酸肌醇受体(IP3R)途径调节动作电位来管理血管张力。所获得的结果证实了预期结果,即中药在BPAid中的益处能够满足对抗高血压病因中涉及的多种信号机制途径的标准。此外,本研究还利用三步傅里叶变换红外光谱法对BPAid的指纹图谱和化学性质进行了鉴定,并与其衍生物进行了比较。所得结果表明,BPAid产生的大多数血管舒张作用归因于皂苷和含芳香环的血管活性化合物的存在。


Hypertension, one of the famous "silent killers" that can attack people at any age, is a current hot topic among scientists due to multiple syndromic behavior and concomitant diseases. The new scientific-based Traditional Chinese Medicine (TCM) formulation approach was used in a previous study by combining five TCM herbs, including Gastrodia elata Bl., Uncaria rhynchophylla (Miq.) Miq. ex Havil., Pueraria thomsonii Benth., Panax notoginseng (Burk.) F.H. Chen, and Alisma orientalis (Sam.) Juzep in optimized ratio (named BPAid). The objective of the present study was to evaluate the mechanism pathways employed by BPAid for vasodilatory effect with the use of an in vitro isolated aortic rings assay. Interestingly, all the mechanisms investigated were involved in the BPAid's vasodilation activity in which the majority contributed through the nitric oxide/soluble guanylyl cyclase/cyclic guanosine monophosphate (NO/sGC/cGMP) pathways, followed by prostacyclin (PGI2), β2-adrenergic, and M3-receptors pathways. Furthermore, the BPAid appeared to manage vascular tone by regulating action potential through potassium and both voltage-operated calcium channel and inositol triphosphate receptor (IP3R) pathways. The results obtained has confirmed the expected outcome that the benefits of TCM herbs in BPAid can meet the criteria of counteracting multiple signaling mechanism pathways involved in the etiology of hypertension. In addition to this study, the fingerprints and chemical properties of BPAid was identified by using tri-step Fourier transform infrared spectroscopy and compared with its derivatives. The results obtained suggested that the majority of the vasodilatory effects exerted by BPAid were attributed to the presence of saponins and aromatic ring-containing vasoactive compounds.

Hypertension, one of the famous "silent killers" that can attack people at any age, is a current hot topic among scientists due to multiple syndromic behavior and concomitant diseases. The new scientific-based Traditional Chinese Medicine (TCM) formulation approach was used in a previous study by combining five TCM herbs, including Gastrodia elata Bl., Uncaria rhynchophylla (Miq.) Miq. ex Havil., Pueraria thomsonii Benth., Panax notoginseng (Burk.) F.H. Chen, and Alisma orientalis (Sam.) Juzep in optimized ratio (named BPAid). The objective of the present study was to evaluate the mechanism pathways employed by BPAid for vasodilatory effect with the use of an in vitro isolated aortic rings assay. Interestingly, all the mechanisms investigated were involved in the BPAid's vasodilation activity in which the majority contributed through the nitric oxide/soluble guanylyl cyclase/cyclic guanosine monophosphate (NO/sGC/cGMP) pathways, followed by prostacyclin (PGI2), β2-adrenergic, and M3-receptors pathways. Furthermore, the BPAid appeared to manage vascular tone by regulating action potential through potassium and both voltage-operated calcium channel and inositol triphosphate receptor (IP3R) pathways. The results obtained has confirmed the expected outcome that the benefits of TCM herbs in BPAid can meet the criteria of counteracting multiple signaling mechanism pathways involved in the etiology of hypertension. In addition to this study, the fingerprints and chemical properties of BPAid was identified by using tri-step Fourier transform infrared spectroscopy and compared with its derivatives. The results obtained suggested that the majority of the vasodilatory effects exerted by BPAid were attributed to the presence of saponins and aromatic ring-containing vasoactive compounds.


获取全文 10.1089/jmf.2017.3958