角膜塑形术对近视进展的影响:一项回顾性队列研究的12年结果。

PubMed ID
发表日期 2017年Dec月

原始出处 眼科学
BMC ophthalmology
作者 Lee  Yueh-Chang  Wang  Jen-Hung  Chiu  Cheng-Jen 

文献标题 角膜塑形术对近视进展的影响:一项回顾性队列研究的12年结果。
Effect of Orthokeratology on myopia progression: twelve-year results of a retrospective cohort study.

文献摘要 BACKGROUND

一些研究报道了角膜塑形术控制近视的疗效。不知何故,有有限的出版与后续超过3年 年。本研究的目的是研究过夜角膜塑形术是否会影响近视儿童在较长的随访期内(最多12个月)明显屈光不正的进展率 年)。若有进展率的改变,则探讨屈光变化与不同基线因素的关系,包括屈光误差、配戴年龄和晶状体更换频率。此外,本研究收集过夜角膜塑形术的长期安全性资料。

METHODS

这是一项对在1998年1月至2013年12月期间接受整夜角膜塑形术矫正的66名学龄儿童的回顾性研究。选择基线年龄和屈光不正与角膜塑形术组匹配的36名受试者作为对照组。这些受试者至少随访了12个月 月。获得明显屈光、睫状肌麻痹屈光、未矫正和最佳矫正视力、散光功率向量、角膜曲率和晶状体置换频率进行分析。

RESULTS

203只眼的数据来自66名角膜塑形术受试者(31名男性和35名女性)和36名对照受试者(22名男性和14名女性)。他们的穿着年龄从7岁到20岁不等 16岁以下 年(平均 ± 东南,11.72 ± 0.18 年)。随访时间为1 第13年 年(平均 ± 东南,6.32 ± 0.15 年)。在基线检查时,他们的近视范围为-0.5 D至-8.0 D(平均值) ± 东南,-3.70 ± 散光范围为0~3.0d(平均值) ± 东南,-0.55 ± 0.05天)。角膜塑形术组与对照组比较有显著性差异(p < 0.001)随访期间屈光不正变化趋势较低。根据GEE模型的分析结果,散光功率越大,屈光不正的变化越大。

CONCLUSIONS

经过12年的随访,整夜角膜塑形术在减缓近视进展方面是有效的,并且证明了临床上可接受的安全性。初始较高的散光功率与随访期间屈光不正的变化增加有关。


BACKGROUND

Several studies reported the efficacy of orthokeratology for myopia control. Somehow, there is limited publication with follow-up longer than 3 years. This study aims to research whether overnight orthokeratology influences the progression rate of the manifest refractive error of myopic children in a longer follow-up period (up to 12 years). And if changes in progression rate are found, to investigate the relationship between refractive changes and different baseline factors, including refraction error, wearing age and lens replacement frequency. In addition, this study collects long-term safety profile of overnight orthokeratology.

METHODS

This is a retrospective study of sixty-six school-age children who received overnight orthokeratology correction between January 1998 and December 2013. Thirty-six subjects whose baseline age and refractive error matched with those in the orthokeratology group were selected to form control group. These subjects were followed up at least for 12 months. Manifest refractions, cycloplegic refractions, uncorrected and best-corrected visual acuities, power vector of astigmatism, corneal curvature, and lens replacement frequency were obtained for analysis.

RESULTS

Data of 203 eyes were derived from 66 orthokeratology subjects (31 males and 35 females) and 36 control subjects (22 males and 14 females) enrolled in this study. Their wearing ages ranged from 7 years to 16 years (mean ± SE, 11.72 ± 0.18 years). The follow-up time ranged from 1 year to 13 years (mean ± SE, 6.32 ± 0.15 years). At baseline, their myopia ranged from -0.5 D to -8.0 D (mean ± SE, -3.70 ± 0.12 D), and astigmatism ranged from 0 D to -3.0 D (mean ± SE, -0.55 ± 0.05 D). Comparing with control group, orthokeratology group had a significantly (p < 0.001) lower trend of refractive error change during the follow-up periods. According to the analysis results of GEE model, greater power of astigmatism was found to be associated with increased change of refractive error during follow-up years.

CONCLUSIONS

Overnight orthokeratology was effective in slowing myopia progression over a twelve-year follow-up period and demonstrated a clinically acceptable safety profile. Initial higher astigmatism power was found to be associated with increased change of refractive error during follow-up years.


获取全文 10.1186/s12886-017-0639-4