雄激素调节Wnt/β-连环蛋白信号在雄激素性脱发中的作用。

PubMed ID
发表日期 2018年Jul月

原始出处 皮肤病研究档案
Archives of dermatological research
作者 Premanand  A  Reena Rajkumari  B 

文献标题 雄激素调节Wnt/β-连环蛋白信号在雄激素性脱发中的作用。
Androgen modulation of Wnt/β-catenin signaling in androgenetic alopecia.

文献摘要

雄激素性脱发(AGA)是一种头皮脱发的皮肤病,其特征是毛囊逐渐缩小,生长期缩短,导致头皮上的毛发数量减少。这是一种复杂的多基因特性,约占男性人口的三分之二。5α-二氢睾酮和雄激素受体的高表达是AGA的致病因素。本文综述了雄激素和雄激素受体(AR)反式激活活性在雄激素性脱发秃顶头皮毛乳头细胞中调节Wnt/β-连环蛋白信号转导中的作用的最新研究。在此,我们分析了雄激素诱导的毛乳头分泌因子对刺激毛囊中卡他素进入的作用,以及AR和Wnt/β-连环蛋白信号之间的分子相互作用,并简要介绍了针对Wnt/β-连环蛋白信号促进头发生长的替代治疗策略。


Androgenetic alopecia (AGA) is a dermatological disorder of scalp hair loss characterized by a progressive miniaturization of hair follicles with shortened anagen phase leading to a decreased number of hairs on the scalp. It is a complex polygenic trait prevailing around two-thirds of the male population. Elevated expressions of 5α-dihydrotestosterone and androgen receptor are the causal factors for AGA. This review describes recent studies on the role of androgens and androgen receptor (AR) transactivation activity in modulating the Wnt/β-catenin signaling in the dermal papilla cells of the balding scalp in androgenetic alopecia. Here, we analyse the androgen-induced dermal papilla secreted factors on stimulating catagen entry in hair follicles and the molecular cross-talk between AR and Wnt/β-catenin signaling with a brief mention on alternative treatment strategy targeting Wnt/β-catenin signaling for promoting hair growth.


获取全文 10.1007/s00403-018-1826-8