不同类型脑梗死与脑卒中后抑郁及认知障碍的关系。

PubMed ID
发表日期 2018年Jun月

原始出处 医学
Medicine
作者 Tu  Jun  Wang  Ling-Xiao  Wen  Hong-Feng  Xu  Yi-Cheng  Wang  Pei-Fu 

文献标题 不同类型脑梗死与脑卒中后抑郁及认知障碍的关系。
The association of different types of cerebral infarction with post-stroke depression and cognitive impairment.

文献摘要

本研究的目的是调查不同类型脑梗死患者的卒中后抑郁(PSD)和认知障碍,纳入我院2015年1月至2016年2月收治的110例脑梗死患者。PSD患者47例,非PSD患者63例。采用汉密尔顿抑郁量表(HAMD)和简易精神状态检查(MMSE)对PSD患者的抑郁和认知功能进行评定,部分前循环梗死(PACI)患者的比例(68.75%)明显高于腔隙性循环梗死(LACI)患者,29.17%和后循环梗死(POCI,26.67%)(P<0.05)。PSD患者LACI与POCI无显著性差异(P>0.05)。PACI组MMSE评分(18.05±2.61)低于POCI组和LACI组(P<0.05),而LACI组和POCI组MMSE评分无显著性差异(P>0.05)。PACI、LACI和POCI患者认知功能障碍发生率分别为12.50%、14.58%和13.33%。PSD患者MMSE评分(21.23±2.12)明显低于非PSD患者(P<0.05),与LACI和POCI患者相比,PACI患者PSD发生率和认知功能损害发生率较高。此外,情感障碍如抑郁症可能与脑梗死患者的认知障碍有关。


The aim of this study was to investigate post-stroke depression (PSD) and cognitive impairments in patients with different types of cerebral infarction.A total of 110 patients with cerebral infarction treated in our hospital from January 2015 to February 2016 were included in present study. Forty-seven patients were PSD patients and 63 patients were non-PSD patients. The Hamilton Depression Rating Scale (HAMD) and Mini-Mental State Examination (MMSE) were employed to assess depression and cognition of patientsAmong PSD patients, the proportion of patients with partial anterior circulation infarction (PACI, 68.75%) was significantly higher than patients with lacunar circulation infarction (LACI, 29.17%) and posterior circulation infarction (POCI, 26.67%) (P < .05). No significant difference was found in PSD patients with LACI and POCI (P > .05). The MMSE score of patients with PACI (18.05 ± 2.61) was lower than patients with POCI and LACI (P < .05), however, no significant difference was found in patients with LACI and POCI (P > 0.05). The incidences of cognitive impairment in patients with PACI, LACI, and POCI were 12.50%, 14.58%, and 13.33%, respectively. The MMSE score of PSD patients (21.23 ± 2.12) was significantly lower than non-PSD patients (P < .05).Compared with LACI and POCI patients, PACI patients had a higher incidence of PSD and impaired cognitive functions. In addition, affective disorders such as depression may be correlated with cognitive impairment in patients with cerebral infarction.


获取全文 10.1097/MD.0000000000010919