女性中的雄激素:雄激素介导的皮肤病和患者评价。

PubMed ID
G H
发表日期 2019年Jun月

原始出处 美国皮肤病学会杂志
Journal of the American Academy of Dermatology
作者 Bienenfeld  Amanda  Azarchi  Sarah  Lo Sicco  Kristen  Marchbein  Shari  Shapiro  Jerry  Nagler  Arielle R 

文献标题 女性中的雄激素:雄激素介导的皮肤病和患者评价。
Androgens in women: Androgen-mediated skin disease and patient evaluation.
Androgens in women: Androgen-mediated skin disease and patient evaluation.

文献摘要

雄激素在全身产生于类固醇的器官,如肾上腺和卵巢,以及其他组织,如皮肤。女性体内通常含有几种雄激素,包括脱氢表雄酮、硫酸脱氢表雄酮、睾酮、双氢睾酮和雄烯二酮。这些雄激素在女性常见皮肤病的发展中是必不可少的,包括痤疮、多毛症和女性型脱发(FPHL)-雄激素介导的皮肤病(AMCD)。然而,雄激素在这些疾病的病理生理学中的作用是复杂和不完全的。在继续医学教育系列的第一篇文章中,我们将讨论皮肤在雄激素产生中的作用以及雄激素对女性皮肤的影响。具体来说,我们回顾了雄激素在女性痤疮、多毛症和FPHL发展中所起的必要但不充分的作用。皮肤科医生面临的挑战是如何区分女性AMCDs的生理和病理表现。目前还没有皮肤科指南概述的迹象内分泌评估妇女提出痤疮,多毛症,或FPHL。我们回顾现有的证据,关于何时考虑内分泌治疗的妇女提出AMCDs,包括适当的类型和时间的测试。


Androgens are produced throughout the body in steroid-producing organs, such as the adrenal glands and ovaries, and in other tissues, like the skin. Several androgens are found normally in women, including dehydroepiandrosterone, dehydroepiandrosterone-sulfate, testosterone, dihydrotestosterone, and androstenedione. These androgens are essential in the development of several common cutaneous conditions in women, including acne, hirsutism, and female pattern hair loss (FPHL)-androgen-mediated cutaneous disorders (AMCDs). However, the role of androgens in the pathophysiology of these diseases is complicated and incompletely understood. In the first article in this Continuing Medical Education series, we discuss the role of the skin in androgen production and the impact of androgens on the skin in women. Specifically, we review the necessary but insufficient role that androgens play in the development of acne, hirsutism, and FPHL in women. Dermatologists face the challenge of differentiating physiologic from pathologic presentations of AMCDs in women. There are currently no dermatology guidelines outlining the indications for endocrinologic evaluation in women presenting with acne, hirsutism, or FPHL. We review the available evidence regarding when to consider an endocrinologic workup in women presenting with AMCDs, including the appropriate type and timing of testing.

Androgens are produced throughout the body in steroid-producing organs, such as the adrenal glands and ovaries, and in other tissues, like the skin. Several androgens are found normally in women, including dehydroepiandrosterone, dehydroepiandrosterone-sulfate, testosterone, dihydrotestosterone, and androstenedione. These androgens are essential in the development of several common cutaneous conditions in women, including acne, hirsutism, and female pattern hair loss (FPHL)-androgen-mediated cutaneous disorders (AMCDs). However, the role of androgens in the pathophysiology of these diseases is complicated and incompletely understood. In the first article in this Continuing Medical Education series, we discuss the role of the skin in androgen production and the impact of androgens on the skin in women. Specifically, we review the necessary but insufficient role that androgens play in the development of acne, hirsutism, and FPHL in women. Dermatologists face the challenge of differentiating physiologic from pathologic presentations of AMCDs in women. There are currently no dermatology guidelines outlining the indications for endocrinologic evaluation in women presenting with acne, hirsutism, or FPHL. We review the available evidence regarding when to consider an endocrinologic workup in women presenting with AMCDs, including the appropriate type and timing of testing.


获取全文 10.1016/j.jaad.2018.08.062