钩藤及其中枢神经系统主要成分的药理作用研究进展。

PubMed ID
发表日期 2020年月

原始出处 当代血管药理学
Current vascular pharmacology
作者 Yang  Wen  Ip  Siu-Po  Liu  Ling  Xian  Yan-Fang  Lin  Zhi-Xiu 

文献标题 钩藤及其中枢神经系统主要成分的药理作用研究进展。
Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions.

文献摘要 BACKGROUND

钩藤属钩藤属(Uncaria rhynchophylla,Miq.)Jacks(Rubinaceae),是中医界常用的治疗惊厥、高血压、癫痫、子痫等脑部疾病的常用中药。钩藤的主要活性成分是生物碱、萜类和黄酮类化合物。钩藤及其主要成分对中枢神经系统的保护作用是近年来研究的热点。

OBJECTIVE

本研究旨在系统总结钩藤及其主要成分对中枢神经系统的药理作用。

METHODS

这篇综述总结了我们实验室的实验结果,以及通过全面搜索数据库(包括Pubmed和科学网)获得的其他文献数据。

RESULTS

U、 钩藤及其主要成分如钩藤碱和异钩藤碱已被证明通过抗氧化、抗炎和调节神经递质等多种机制对阿尔茨海默病、帕金森病、抑郁症、脑缺血具有神经保护作用。

CONCLUSION

U、 钩藤及其主要成分对中枢神经系统有多种有益的药理作用。对钩藤及其主要成分的进一步研究有助于充分阐明这些天然化合物的潜在分子机制、药代动力学和毒理学特征及其临床应用潜力。


BACKGROUND

Uncaria rhynchophylla (Miq.) Jacks (Rubinaceae), a common herbal medicine known as Gou-teng in Chinese, is commonly used in Chinese medicine practice for the treatment of convulsions, hypertension, epilepsy, eclampsia and other cerebral diseases. The major active components of U. rhynchophylla are alkaloids, terpenoids and flavonoids. The protective effects of U. rhynchophylla and its major components on central nervous system (CNS) have become a focus of research in recent decades.

OBJECTIVE

The study aimed to systematically summarize the pharmacological activities of U. rhynchophylla and its major components on the CNS.

METHODS

This review summarized the experimental findings from our laboratories, together with other literature data obtained through a comprehensive search of databases including the Pubmed and the Web of Science.

RESULTS

U. rhynchophylla and its major components such as rhynchophylline and isorhynchophylline have been shown to have neuroprotective effects on Alzheimer's disease, Parkinson's disease, depression, cerebral ischaemia through a number of mechanisms including anti-oxidant, anti-inflammatory actions and regulation on neurotransmitters.

CONCLUSION

U. rhynchophylla and its major components have multiple beneficial pharmacological effects on CNS. Further studies on U. rhynchophylla and its major components are warranted to fully illustrate the underlying molecular mechanisms, pharmacokinetics, and toxicological profiles of these naturally occurring compounds and their potential for clinical application.


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