钩藤及其中枢神经系统主要成分药理作用的研究进展。

PubMed ID
G H
发表日期 2020年月

原始出处 现代血管药理学
Current vascular pharmacology
作者 Yang  Wen  Ip  Siu-Po  Liu  Ling  Xian  Yan-Fang  Lin  Zhi-Xiu 

文献标题 钩藤及其中枢神经系统主要成分药理作用的研究进展。
Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions.
Uncaria rhynchophylla and its Major Constituents on Central Nervous System: A Review on Their Pharmacological Actions.

文献摘要 BACKGROUND

钩藤(钩藤科)是一种常见的中草药,在中医中被称为钩藤,常用于治疗惊厥、高血压、癫痫、子痫等脑部疾病。美国的主要活性成分。钩藤是生物碱、萜类和黄酮类化合物。美国的保护作用。钩藤及其主要成分对中枢神经系统的影响是近几十年来研究的热点。

OBJECTIVE

本研究旨在系统地总结乌药的药理作用。钩藤及其在中枢神经系统中的主要成分。

METHODS

本文综述了我们实验室的实验结果,以及通过综合检索Pubmed和科学网等数据库获得的其他文献资料。

RESULTS

美国。钩藤及其主要成分钩藤碱和异钩藤碱通过抗氧化、抗炎和调节神经递质等多种机制对阿尔茨海默病、帕金森病、抑郁症、脑缺血具有神经保护作用。

CONCLUSION

美国。钩藤及其主要成分对中枢神经系统具有多种有益的药理作用。对美国的进一步研究。钩藤及其主要成分有必要充分说明这些天然化合物的分子机制、药代动力学和毒理学特征及其临床应用潜力。


BACKGROUND

Uncaria rhynchophylla (Miq.) Jacks (Rubinaceae), a common herbal medicine known as Gou-teng in Chinese, is commonly used in Chinese medicine practice for the treatment of convulsions, hypertension, epilepsy, eclampsia and other cerebral diseases. The major active components of U. rhynchophylla are alkaloids, terpenoids and flavonoids. The protective effects of U. rhynchophylla and its major components on central nervous system (CNS) have become a focus of research in recent decades.

OBJECTIVE

The study aimed to systematically summarize the pharmacological activities of U. rhynchophylla and its major components on the CNS.

METHODS

This review summarized the experimental findings from our laboratories, together with other literature data obtained through a comprehensive search of databases including the Pubmed and the Web of Science.

RESULTS

U. rhynchophylla and its major components such as rhynchophylline and isorhynchophylline have been shown to have neuroprotective effects on Alzheimer's disease, Parkinson's disease, depression, cerebral ischaemia through a number of mechanisms including anti-oxidant, anti-inflammatory actions and regulation on neurotransmitters.

CONCLUSION

U. rhynchophylla and its major components have multiple beneficial pharmacological effects on CNS. Further studies on U. rhynchophylla and its major components are warranted to fully illustrate the underlying molecular mechanisms, pharmacokinetics, and toxicological profiles of these naturally occurring compounds and their potential for clinical application.

BACKGROUND

Uncaria rhynchophylla (Miq.) Jacks (Rubinaceae), a common herbal medicine known as Gou-teng in Chinese, is commonly used in Chinese medicine practice for the treatment of convulsions, hypertension, epilepsy, eclampsia and other cerebral diseases. The major active components of U. rhynchophylla are alkaloids, terpenoids and flavonoids. The protective effects of U. rhynchophylla and its major components on central nervous system (CNS) have become a focus of research in recent decades.

OBJECTIVE

The study aimed to systematically summarize the pharmacological activities of U. rhynchophylla and its major components on the CNS.

METHODS

This review summarized the experimental findings from our laboratories, together with other literature data obtained through a comprehensive search of databases including the Pubmed and the Web of Science.

RESULTS

U. rhynchophylla and its major components such as rhynchophylline and isorhynchophylline have been shown to have neuroprotective effects on Alzheimer's disease, Parkinson's disease, depression, cerebral ischaemia through a number of mechanisms including anti-oxidant, anti-inflammatory actions and regulation on neurotransmitters.

CONCLUSION

U. rhynchophylla and its major components have multiple beneficial pharmacological effects on CNS. Further studies on U. rhynchophylla and its major components are warranted to fully illustrate the underlying molecular mechanisms, pharmacokinetics, and toxicological profiles of these naturally occurring compounds and their potential for clinical application.


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