多药患者设计的3D打印药物的感知、偏好和可接受性:一项初步研究。

PubMed ID
发表日期 2019年Oct月

原始出处 国际临床药学杂志
International journal of clinical pharmacy
作者 Fastø  Mark Møller  Genina  Natalja  Kaae  Susanne  Kälvemark Sporrong  Sofia 

文献标题 多药患者设计的3D打印药物的感知、偏好和可接受性:一项初步研究。
Perceptions, preferences and acceptability of patient designed 3D printed medicine by polypharmacy patients: a pilot study.

文献摘要

背景3D打印与传统的药物制造技术相比,是一种多用途、高度可修改的技术,它具有生产满足患者特定要求(如个体化给药)的药物的灵活性,同时还可以定制剂型的外观(如形状和颜色)。目的探讨多药性患者对3D打印药物的认知和偏好,包括对患者设计药物的可接受性。这项研究是在丹麦的新西兰进行的。方法采用方便抽样法(主要在Facebook上)招募多发性药物患者,采用半结构化访谈法进行两次访谈。访谈按主题分为五个预先确定的主题(形状、颜色、压花设计、息肉和患者设计的剂型)。在第一次访谈中,患者被问及他们对3D打印固体剂型的看法和偏好,并被呈现出不同的形状、颜色、压花设计和息肉病的例子。他们还被邀请从所展示的药物中设计自己的药物。在第二次访谈中,他们介绍了自己设计的药物,调查了他们自己设计的药物的可接受性和自己设计药物的概念。主要结果衡量患者对3D打印药物的认知、偏好和可接受性。结果共8例。他们倾向于选择与传统医学相似的形状。不同的人喜欢不同的颜色。呈现的浮雕设计似乎无关紧要。由于药物数量的减少,人们普遍认为息肉病是一个好主意。病人设计药物的可接受性主要取决于病人是否认为三维打印技术是可靠的。结论患者对3D打印医学有不同的认知和偏好。影响患者观点的因素有审美(吸引力)、生理(吞咽)、实践(处理)、教学(理解)和心理(相关)。对这项技术的信任似乎对可接受性很重要。


Background 3D-printing, compared to conventional medicine manufacturing technologies, is a versatile and highly modifiable technique that has the flexibility to produce medicine that meet patients' specific requirements such as individualized dosing, but also to customize the appearance of the dosage form, e.g., shape and colour. Objective To explore polypharmacy patients' perceptions and preferences regarding 3D-printed medicine, including their acceptability of patient-designed medicine. Setting The study was conducted in Zealand, Denmark. Method Polypharmacy patients were recruited using convenience sampling (mostly on Facebook) and interviewed twice using semi-structured interviews. Interviews were analysed thematically into five predetermined themes (shapes, colours, embossing designs, polypills, and patient-designed dosage forms). At the first interview patients were asked about their perceptions and preferences towards 3D-printed solid dosage forms, and were presented to different shapes, colours, embossing designs and examples of polypills. They were also invited to design their own medicine from the ones presented. Their self-designed medicines were presented at the second interview, where acceptability of both their self-designed medicine and the concept of designing one's own medicine, was investigated. Main outcome measure Patients' perceptions, preferences towards and acceptability of 3D-printed medicines. Results Eight patients were included. They tended to prefer shapes similar to conventional medicine. Different colours were preferred by different people. The presented embossing designs seemed to be irrelevant. Polypills were generally believed to be a good idea due to the reduction of number of medicines. Acceptability of patient-designed medicine was mainly determined by whether patients thought 3Dprinting technology was reliable or not. Conclusions The patients had various perceptions and preferences of 3D-printed medicine. Factors affecting the patient views were aesthetic (appealing), physiological (swallowing), practical (handling), pedagogical (understanding) and psychological (relate to). Trust in the technology seemed to be important for acceptability.


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