长期角膜塑形术反应与角膜生物力学的关系。

PubMed ID
发表日期 2019年08月

原始出处 科学报告
Scientific reports
作者 Lam  Andrew K C  Hon  Ying  Leung  Stanley Y Y  Shu-Ho  Lu  Chong  Jones  Lam  David C C 

文献标题 长期角膜塑形术反应与角膜生物力学的关系。
Association between long-term orthokeratology responses and corneal biomechanics.

文献摘要

近视在世界范围内非常普遍,尤其是在亚洲人群中。角膜塑形术是减少近视进展的有效措施。本研究探讨了基线角膜生物力学与角膜塑形术反应之间的关系,以及长期角膜塑形术后角膜生物力学的变化。我们为59名近视眼年龄在-4.00D到-5.00D之间的成年受试者安装了过夜角膜塑形术。通过动态双向角膜压平(角膜滞后、CH和角膜阻力因子)和角膜压痕(角膜刚度、S和切线模量)测量角膜生物力学。角膜塑形术反应差的受试者E值较低(平均0.474) MPa)高于角膜塑形术反应良好者(平均0.536) 兆帕)。成功的角膜塑形术6个月后,CH(减少5.8%)和CRF(减少8.7%)。角膜硬度稳定,但E呈上升趋势。在角膜塑形术成功的受试者中,较高的基线S导致较大的近视减少(皮尔逊相关系数,r = 0.381,p = 0.02).


Myopia is very prevalent worldwide, especially among Asian populations. Orthokeratology is a proven intervention to reduce myopia progression. The current study investigated association between baseline corneal biomechanics and orthokeratology responses, and changes of corneal biomechanics from long-term orthokeratology. We fitted 59 adult subjects having myopia between -4.00D to -5.00D with overnight orthokeratology. Corneal biomechanics was measured through dynamic bidirectional corneal applanation (in terms of corneal hysteresis, CH and corneal resistance factor, CRF) and corneal indentation (in terms of corneal stiffness, S and tangent modulus, E). Subjects with poor orthokeratology responses had lower E (mean 0.474 MPa) than subjects with good orthokeratology responses (mean 0.536 MPa). Successful orthokeratology for 6 months resulted in reducing CH (reduced by 5.8%) and CRF (reduced by 8.7%). Corneal stiffness was stable, but E showed an increasing trend. Among subjects with successful orthokeratology, a higher baseline S resulted in greater myopia reduction (Pearson correlation coefficient, r = 0.381, p = 0.02).


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