杜仲提取物七种有效成分在正常和自发性高血压大鼠肠内循环灌注吸收动力学的比较。

PubMed ID
发表日期 2020年Jan月

原始出处 生物医学色谱:BMC
Biomedical chromatography : BMC
作者 Hu  Hejia  Wu  Linlin  Li  Mei  Xue  Cun  Wang  Guangcheng  Chen  Siying  Huang  Yong  Zheng  Lin  Wang  Aimin  Li  Yueting  Gong  Zipeng 

文献标题 杜仲提取物七种有效成分在正常和自发性高血压大鼠肠内循环灌注吸收动力学的比较。
Comparative absorption kinetics of seven active ingredients of Eucommia ulmoides extracts by intestinal in situ circulatory perfusion in normal and spontaneous hypertensive rats.

文献摘要

杜仲。榆树是我国珍贵的滋补药材,用于治疗高血压病。鉴于大多数中药主要用于治疗疾病,研究中医药在病理状态下的药代动力学比研究正常状态下的药代动力学更有意义。然而,在病理和生理条件下,尺蠖提取物活性成分的吸收动力学差异尚未报道。因此,本研究采用大鼠肠道原位循环灌流模型,研究了正常和自发性高血压大鼠对榆叶提取物7种活性成分的吸收动力学差异,即genipinic acid、原儿茶酸、新绿原酸、绿原酸、隐绿原酸、原儿茶酸,(+)-松脂醇二-O-β-D-吡喃葡萄糖苷和(+)-松脂醇4'-O-β-D-吡喃葡萄糖苷。本研究结果提示,自发性高血压病的病理状态可能会改变尺蠖提取物中有效成分的吸收,为临床合理使用尺蠖提供参考。


Eucommia ulmoides Oliv. (E. ulmoides) is a valuable and nourishing medicinal herb in China that has been used in the treatment of hypertension. Given the fact that most traditional Chinese medicine is mainly used to treat disease, investigating the pharmacokinetics of traditional Chinese medicines in the pathological state is more useful than that in the normal state. However, the differences in the absorption kinetics of active ingredients of E. ulmoides extract between pathological and physiological conditions have not been reported. Therefore, in this study, the rat intestinal in situ circulatory perfusion model was used to investigate the differences in absorption kinetics of seven active ingredients of E. ulmoides extract in normal and spontaneously hypertensive rats, namely, genipinic acid, protocatechuic acid, neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, (+)-pinoresinol di-O-β-D-glucopyranoside and (+)-pinoresinol 4'-O-β-D-glucopyranoside. Our results indicate that the pathological state of spontaneous hypertension may change the absorption of active components of E. ulmoides extracts, and these findings may provide a reference for improving the rational use of E. ulmoides in the clinic.


获取全文 10.1002/bmc.4714