小关节退变对C5-C6颈椎应力变化的影响:有限元分析。

PubMed ID
G H
发表日期 2019年08月

原始出处 数学生物科学与工程:分子生物学
Mathematical biosciences and engineering : MBE
作者 Wang  Hui Hao  Wang  Kuan  Deng  Zhen  Li  Xiao Fei  Qin  Yi-Xian  Zhan  Hong Sheng  Niu  Wen Xin 

文献标题 小关节退变对C5-C6颈椎应力变化的影响:有限元分析。
Effects of facet joint degeneration on stress alterations in cervical spine C5-C6: A finite element analysis.
Effects of facet joint degeneration on stress alterations in cervical spine C5-C6: A finite element analysis.

文献摘要

已有研究表明,关节突退变可引起局部应变改变,诱发颈痛。本研究旨在量化正常和退变的C5-C6关节面生物力学效应,并评价正常和退变脊柱力学应变的相关性。建立了C5-C6颈椎的三维有限元模型[模型0(M0)]。分别建立C5~C6双侧关节突关节不对称模型,模拟关节突关节退变。以最小阈值和最大阈值改变C5-C6单侧小关节囊膜韧带刚度,模拟囊膜韧带损伤和钙化[模型1(M1)和模型2(M2)]。同时,将颈C5-C6单侧关节突关节方向前移5°和10°,模拟中度关节增生和重度骨赘(分别为模型3和模型4)。M1使同侧(左)旋转范围增大,M2减小,对侧(右)影响有限。在轴向旋转过程中,模型3(M3)(61°)和模型4(M4)(55°)的角度比M0增大,且M4的角度更大。在轴向旋转过程中,M3和M4在有或无控制角位移的情况下增加了髓核压力。M1向异常侧旋转时,髓核压力升高,向另一侧旋转时,髓核压力降低,而M2的结果相反。关节囊韧带刚度影响节段活动度和椎体空间位置,关节小关节矢状角影响椎间盘压力分布。


It has been demonstrated that articular facet degeneration can cause local strain alterations and induce neck pain. This study aims to quantify the biomechanical effects of normal and degenerated C5-C6 articular facets, and evaluate the correlation of mechanical strain between healthy and degenerated spine. A 3-dimensional finite element (FE) model of the C5-C6 cervical spine was developed [Model 0 (M0)]. The asymmetric models of C5-C6 bilateral articular facet joint were established separately to mimic articular facet joint degeneration. The capsule ligament stiffness of C5-C6 unilateral facet joint was altered with minimum and maximum threshold to simulate capsule ligaments' lesion and calcification [Model 1 (M1) and Model 2 (M2), respectively]. Besides, the cervical C5-C6 unilateral articular facet joint direction was changed by 5° and 10° forward to imitate the moderate joint hyperplasia and severe osteophyte (Model 3 and Model 4 respectively). M1 increased the rotation range of ipsilateral side (left), while M2 reduced, and both had limited effect on the contralateral side (right). The angle increased in Model 3 (M3) (61°) and Model 4 (M4) (55°) comparing to M0 during the axial rotation, and the angle of M4 was larger. M3 and M4 increased the nucleus pulposus pressure with and without controlled angular displacement during axial rotation. The pressure of nucleus pulpous increased during M1 rotating to the abnormal side but decreased when rotating to the other side, but the results of M2 were opposite. The capsule ligament stiffness made an impact on segmental mobility and vertebral spatial position, and the sagittal angle of articular facet joint exerted an influence on disc pressure distribution.

It has been demonstrated that articular facet degeneration can cause local strain alterations and induce neck pain. This study aims to quantify the biomechanical effects of normal and degenerated C5-C6 articular facets, and evaluate the correlation of mechanical strain between healthy and degenerated spine. A 3-dimensional finite element (FE) model of the C5-C6 cervical spine was developed [Model 0 (M0)]. The asymmetric models of C5-C6 bilateral articular facet joint were established separately to mimic articular facet joint degeneration. The capsule ligament stiffness of C5-C6 unilateral facet joint was altered with minimum and maximum threshold to simulate capsule ligaments' lesion and calcification [Model 1 (M1) and Model 2 (M2), respectively]. Besides, the cervical C5-C6 unilateral articular facet joint direction was changed by 5° and 10° forward to imitate the moderate joint hyperplasia and severe osteophyte (Model 3 and Model 4 respectively). M1 increased the rotation range of ipsilateral side (left), while M2 reduced, and both had limited effect on the contralateral side (right). The angle increased in Model 3 (M3) (61°) and Model 4 (M4) (55°) comparing to M0 during the axial rotation, and the angle of M4 was larger. M3 and M4 increased the nucleus pulposus pressure with and without controlled angular displacement during axial rotation. The pressure of nucleus pulpous increased during M1 rotating to the abnormal side but decreased when rotating to the other side, but the results of M2 were opposite. The capsule ligament stiffness made an impact on segmental mobility and vertebral spatial position, and the sagittal angle of articular facet joint exerted an influence on disc pressure distribution.


获取全文 10.3934/mbe.2019373