高尿酸血症和高血压:联系和风险。

PubMed ID
发表日期 2019年月

原始出处 综合血压控制
Integrated blood pressure control
作者 Stewart  Douglas J  Langlois  Valerie  Noone  Damien 

文献标题 高尿酸血症和高血压:联系和风险。
Hyperuricemia and Hypertension: Links and Risks.

文献摘要

长期以来,高尿酸血症被认为与心血管风险增加有关,包括患高血压的风险。流行病学调查结果表明,儿童和青少年与高血压的关系更为密切。尿酸在细胞外环境中是一种强抗氧化化合物,但在细胞内环境中具有促炎症作用。长期高尿酸血症可导致微血管慢性损伤。这被认为有助于传入性动脉病变和血压升高,随着时间的推移,这些可能对尿酸降低疗法无反应。由于包括体重指数在内的大量混杂因素,研究一直难以推断高尿酸血症的直接因果关系。本综述的目的是介绍现有的数据,并强调在这一领域进行大规模前瞻性随机对照试验的必要性。目前,支持降低尿酸疗法在帮助降低高血压风险方面的作用的证据有限。


Hyperuricemia has long been recognized to be associated with increased cardiovascular risk, including risk of developing hypertension. Epidemiological findings suggest that the link with hypertension is stronger in children and adolescents. Uric acid acts as a strong antioxidant compound in the extracellular environment but has pro-inflammatory effects within the intracellular setting. A chronic phase of microvascular injury is known to occur after prolonged periods of hyperuricemia. This is proposed to contribute to afferent arteriolopathy and elevation of blood pressure that may become unresponsive to uric acid-lowering therapies over time. Studies have struggled to infer direct causality of hyperuricemia due to a vast number of confounders including body mass index. The aim of this review is to present the available data and highlight the need for large scale prospective randomized controlled trials in this area. At present, there is limited evidence to support a role for uric acid-lowering therapies in helping mitigate the risk of hypertension.


获取全文 10.2147/IBPC.S184685