禁止配体:一种用于治疗癌症、骨质疏松症、炎症、心脏和神经系统疾病的日益增长的武器。

PubMed ID
发表日期 2020年Sep月

原始出处 细胞和分子生命科学
Cellular and molecular life sciences : CMLS
作者 Wang  Dong  Tabti  Redouane  Elderwish  Sabria  Abou-Hamdan  Hussein  Djehal  Amel  Yu  Peng  Yurugi  Hajime  Rajalingam  Krishnaraj  Nebigil  Canan G  Désaubry  Laurent 

文献标题 禁止配体:一种用于治疗癌症、骨质疏松症、炎症、心脏和神经系统疾病的日益增长的武器。
Prohibitin ligands: a growing armamentarium to tackle cancers, osteoporosis, inflammatory, cardiac and neurological diseases.

文献摘要

在过去的三十年里,支架蛋白抑制因子-1和-2(PHB1/2)已经成为调节健康和疾病中多种信号通路的关键信号蛋白。以PHBs为靶点的小分子对癌症、骨质疏松症、炎症、心脏和神经退行性疾病具有良好的疗效。本文综述了PHB配体的各种类型,重点介绍了其作用机制和治疗潜力。我们也描述了这些配体是如何被用来探索PHB信号在不同的生理和病理环境。


Over the last three decades, the scaffold proteins prohibitins-1 and -2 (PHB1/2) have emerged as key signaling proteins regulating a myriad of signaling pathways in health and diseases. Small molecules targeting PHBs display promising effects against cancers, osteoporosis, inflammatory, cardiac and neurodegenerative diseases. This review provides an updated overview of the various classes of PHB ligands, with an emphasis on their mechanism of action and therapeutic potential. We also describe how these ligands have been used to explore PHB signaling in different physiological and pathological settings.


获取全文 10.1007/s00018-020-03475-1