阿维A单一疗法成功清除广泛/顽固性皮肤疣:一项病例系列研究。

PubMed ID
发表日期 2020年05月

原始出处 皮肤科治疗
Dermatologic therapy
作者 Zhang  Sanquan  Xu  Xiao  Liu  Yumei  Xue  Rujun  Li  Changxing  Chen  Pingjiao  Zhang  Xibao  Liang  Jingyao 

文献标题 阿维A单一疗法成功清除广泛/顽固性皮肤疣:一项病例系列研究。
Successful clearance of extensive/recalcitrant cutaneous warts by acitretin monotherapy: A case series study.

文献摘要

大多数可用的疣治疗方案都受到疤痕、疼痛、缺乏反应或复发可能性的限制,患者往往无法忍受和接受这些经历。本研究的目的是评估口服阿维A单药治疗广泛/顽固性皮肤疣的临床疗效和安全性。患者服用0.8 mg阿维a kg-1天,每2天评估一次阿维A的临床疗效和安全性 两周,持续两个月。共包括14名患者(12名男性和2名女性),年龄14-60岁 年(平均33 ± 14.7 年),课程为4-48 月(平均21.6 ± 13.4个月)。阿维A治疗2个月后,42.9%(6/14)的患者(包括足部、腿部和手部的疣)表现出完全反应,28.6%(4/14)的患者表现出良好反应,28.6%(4/14)的患者表现出良好反应。所有患者均表现出显著改善,药物耐受性良好,没有患者因副作用而停止治疗。常见的轻度副作用包括皮肤干燥和唇炎。随访6个月,无复发。阿维A单一疗法对不适合或不愿意接受传统治疗方法的广泛/顽固性皮肤疣患者是一种有效、安全且耐受性良好的治疗方法。


Most available options for the treatment of warts are limited by the potential for scarring, pain, lack of response, or recurrences, and the patients are often unable to tolerate and accept those experiences. The aim of this study was to evaluate the clinical efficacy and safety of oral systemic acitretin monotherapy in patients with extensive/recalcitrant cutaneous warts. The patients were given a dose of acitretin of 0.8 mg kg-1 day-1 , and the clinical efficacy and safety of acitretin was assessed every 2 weeks for 2 months. A total of 14 patients (12 males and 2 females) were included, with an age of 14-60 years (mean 33 ± 14.7 years) and a course of 4-48 months (mean 21.6 ± 13.4 months). After 2 months of acitretin treatment, 42.9% (6/14) of patients (including warts of the feet, legs, and hands) exhibited complete response, 28.6% (4/14) excellent response, and 28.6% (4/14) good response. All patients demonstrated significant improvement, and the drug was well tolerated, with no patients discontinuing therapy due to side effects. Common mild side effects included dry skin and cheilitis. There were no recurrences during a follow-up period of 6 months. Acitretin monotherapy is an effective, safe, and well-tolerated treatment for patients with extensive/recalcitrant cutaneous warts who are unsuitable for or unwilling to accept traditional treatment methods.


获取全文 10.1111/dth.13390