雄激素在COVID-19中的作用。

PubMed ID
G H
发表日期 年月

原始出处 糖尿病与代谢综合征
Diabetes & metabolic syndrome
作者 Moradi  Fatemeh  Enjezab  Behnaz  Ghadiri-Anari  Akram 

文献标题 雄激素在COVID-19中的作用。
The role of androgens in COVID-19.
The role of androgens in COVID-19.

文献摘要 BACKGROUND AND AIM

2019年冠状病毒病(COVID-19)大流行是全球卫生紧急事件。根据研究结果,患有COVID-19感染的男性患者发生严重并发症的风险高于女性患者。这个问题的原因是未知的,很可能是多方面的。性激素影响免疫系统,因此雌激素增强免疫系统,睾酮抑制免疫系统。据报道,与非多囊卵巢综合征(PCOS)患者相比,多囊卵巢综合征(PCOS)患者的雄激素性脱发患病率高,呼吸系统疾病风险高,过敏/哮喘药物使用增加,本文旨在探讨雄激素在COVID-19中的作用。

METHODS

以雄激素、激素因子、脱发为关键词,结合COVID-19在医学研究数据库中的应用,对2008-2020年42篇相关文献进行了综述。

RESULTS

跨膜蛋白水解酶丝氨酸2(TMPRSS2)在肺组织中表达的证据可能解释了男性对严重COVID-19并发症的易感性增加。此外,血管紧张素转换酶2(ACE-2)是严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的功能性受体,雄性激素在ACE-2通道中起作用,简化了SARS-CoV-2进入宿主细胞的过程。

CONCLUSION

与对照组相比,建议进一步研究其他高雄激素血症条件下COVID-19患者的症状严重程度。


BACKGROUND AND AIM

The coronavirus disease 2019 (COVID-19) pandemic is a global health emergency. According to the findings, male patients with COVID-19 infection are at an increased risk for severe complications than females. The causes of this issue are unknown and are most probably multifactorial. Sexual hormones affect the immune system, so estrogen strengthens the immune system, and testosterone suppresses it. Due to the reports of the high prevalence of androgenic alopecia in hospitalized patients with COVID-19 and a higher risk of respiratory disease and increased use of allergy/asthma medications among patients with polycystic ovary syndrome (PCOS) as a hyperandrogenism condition compared with non-PCOS women, this review aimed to evaluate androgens role in COVID-19.

METHODS

42 related articles from 2008 to 2020 were reviewed with the keywords of androgens, hormonal factors, and hair loss in combination with COVID-19 in medical research databases.

RESULTS

The evidence of transmembrane protease, serine 2 (TMPRSS2) expression in lung tissue, which is an androgen-regulated gene and expressed mainly in the adult prostate may interpret the increased susceptibility of the male gender to severe COVID-19 complications. Moreover, angiotensin-converting enzyme 2 (ACE-2) acts as a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and male hormones are effective in the ACE-2 passageway and simplify SARS-CoV-2 entry into host cells.

CONCLUSION

Further studies on the severity of symptoms in patients with COVID-19 in other hyperandrogenism conditions compared to the control group are recommended.

BACKGROUND AND AIM

The coronavirus disease 2019 (COVID-19) pandemic is a global health emergency. According to the findings, male patients with COVID-19 infection are at an increased risk for severe complications than females. The causes of this issue are unknown and are most probably multifactorial. Sexual hormones affect the immune system, so estrogen strengthens the immune system, and testosterone suppresses it. Due to the reports of the high prevalence of androgenic alopecia in hospitalized patients with COVID-19 and a higher risk of respiratory disease and increased use of allergy/asthma medications among patients with polycystic ovary syndrome (PCOS) as a hyperandrogenism condition compared with non-PCOS women, this review aimed to evaluate androgens role in COVID-19.

METHODS

42 related articles from 2008 to 2020 were reviewed with the keywords of androgens, hormonal factors, and hair loss in combination with COVID-19 in medical research databases.

RESULTS

The evidence of transmembrane protease, serine 2 (TMPRSS2) expression in lung tissue, which is an androgen-regulated gene and expressed mainly in the adult prostate may interpret the increased susceptibility of the male gender to severe COVID-19 complications. Moreover, angiotensin-converting enzyme 2 (ACE-2) acts as a functional receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and male hormones are effective in the ACE-2 passageway and simplify SARS-CoV-2 entry into host cells.

CONCLUSION

Further studies on the severity of symptoms in patients with COVID-19 in other hyperandrogenism conditions compared to the control group are recommended.


获取全文 10.1016/j.dsx.2020.10.014