[男性高雄激素血症特征]。

PubMed ID
G H
发表日期 2021年Mar月

原始出处 内磷虾学问题
Problemy endokrinologii
作者 Filatova  V A  Rozhivanov  R V 

文献标题 [男性高雄激素血症特征]。
[Features of hyperandrogenism in men].
[Features of hyperandrogenism in men].

文献摘要 BACKGROUND

今天,女性高雄激素血症的问题已被广泛研究和讨论,而男性高雄激素血症的问题却很少被提及。在临床实践中,高雄激素血症可能是许多疾病的原因。

AIM

提供男性生理性高雄激素血症的变化特征。

MATERIALS AND METHODS

С100例高雄激素血症男性的连续横断面研究。该研究评估了前列腺的体积和结构,睾丸的体积;黄体生成素(LH)、总睾酮、性激素结合球蛋白(SHBG)的水平通过根据Vermeullen进一步计算游离睾酮水平和双氢睾酮(DHT)来确定。根据对高雄激素血症患者激素状态的分析结果,形成了4组患者:1-总睾酮和SHBG水平升高的患者;2-总睾酮水平升高且SHBG水平正常的患者;3-总睾酮水平升高的患者,SHBG水平正常的DHT患者;4-DHT水平升高且总睾酮和SHBG水平正常的患者。测定各组患者之间的差异,p值<0.05被认为具有统计学意义。

RESULTS

第1组患者的年龄和前列腺体积在统计学上显著高于其他组。这一组,尽管总睾酮水平很高,但没有痤疮的症状。第2组患者更常抱怨痤疮,但即使在本组患者中,该症状的患病率也明显低于第3组患者。同时,第2组的秃发发生率在统计学上显著低于第3组和第4组。第3组的患者具有最显著的高雄激素血症临床表现。第4组以脱发为特征。

CONCLUSION

在任何年龄都可以检测到雄激素水平的增加。同时,在老年男性中,总睾酮水平的增加可能是由于SHBG分泌的增加,而不是伴随着游离睾酮水平的增加。在年轻患者中,高雄激素血症的临床表现可能有所不同:DHT水平升高的患者以雄激素性脱发为特征;痤疮在总睾酮和游离睾酮水平升高的男性中很常见,而DHT的增加会加剧这个问题。


BACKGROUND

Today the problem of hyperandrogenism in women is a widely studied and discussed while same issue in relation to men is barely raised. In clinical practice, hyperandrogenism can be the cause of a number of diseases.

AIM

Provide characterization the variations of physiological hyperandrogenism in men.

MATERIALS AND METHODS

Сontinuous cross-sectional study of 100 men with hyperandrogenism. The study assessed the volume and structure of the prostate, the volume of the testicles; the levels of luteinizing hormone (LH), total testosterone, sex hormone binding globulin (SHBG) were determined with further calculation of the level of free testosterone according to Vermeullen, and dihydrotestosterone (DHT). Based on the results of the analysis of the hormonal status of patients with hyperandrogenism, 4 groups of patients were formed: 1-patients with increased total testosterone and SHBG levels; 2-patients with elevated total testosterone levels and normal SHBG levels; 3-patients with an increased level of total testosterone, DHT with a normal level of SHBG; 4-patients with an increased level of DHT with normal levels of total testosterone and SHBG. The difference between groups of patients was determined, a p-value <0.05 was considered statistically significant.

RESULTS

The age and volume of the prostate in group 1 patients were statistically significantly higher than in the other groups. This group, despite the high level of total testosterone, was not characterized by complaints of acne. Group 2 patients complained of acne more often, but the prevalence of this symptom even in this group was statistically significantly lower than in group 3 patients. At the same time, the frequency of occurrence of alopecia was statistically significantly lower in group 2 than in patients of both groups 3 and 4. Patients of group 3 had the most striking clinical manifestations of hyperandrogenism. Group 4 was characterized by alopecia.

CONCLUSION

An increase of androgen levels can be detected at any age. At the same time, in men of the older age group, an increase in the level of total testosterone may be due to an increase in the secretion of SHBG and not be accompanied by an increase in the level of free testosterone. In young patients, the clinical manifestations of hyperandrogenism may differ: patients with elevated DHT levels are characterized by androgenic alopecia; acne is common in men with elevated total and free testosterone levels, and increased DHT exacerbates the problem.

BACKGROUND

Today the problem of hyperandrogenism in women is a widely studied and discussed while same issue in relation to men is barely raised. In clinical practice, hyperandrogenism can be the cause of a number of diseases.

AIM

Provide characterization the variations of physiological hyperandrogenism in men.

MATERIALS AND METHODS

Сontinuous cross-sectional study of 100 men with hyperandrogenism. The study assessed the volume and structure of the prostate, the volume of the testicles; the levels of luteinizing hormone (LH), total testosterone, sex hormone binding globulin (SHBG) were determined with further calculation of the level of free testosterone according to Vermeullen, and dihydrotestosterone (DHT). Based on the results of the analysis of the hormonal status of patients with hyperandrogenism, 4 groups of patients were formed: 1-patients with increased total testosterone and SHBG levels; 2-patients with elevated total testosterone levels and normal SHBG levels; 3-patients with an increased level of total testosterone, DHT with a normal level of SHBG; 4-patients with an increased level of DHT with normal levels of total testosterone and SHBG. The difference between groups of patients was determined, a p-value <0.05 was considered statistically significant.

RESULTS

The age and volume of the prostate in group 1 patients were statistically significantly higher than in the other groups. This group, despite the high level of total testosterone, was not characterized by complaints of acne. Group 2 patients complained of acne more often, but the prevalence of this symptom even in this group was statistically significantly lower than in group 3 patients. At the same time, the frequency of occurrence of alopecia was statistically significantly lower in group 2 than in patients of both groups 3 and 4. Patients of group 3 had the most striking clinical manifestations of hyperandrogenism. Group 4 was characterized by alopecia.

CONCLUSION

An increase of androgen levels can be detected at any age. At the same time, in men of the older age group, an increase in the level of total testosterone may be due to an increase in the secretion of SHBG and not be accompanied by an increase in the level of free testosterone. In young patients, the clinical manifestations of hyperandrogenism may differ: patients with elevated DHT levels are characterized by androgenic alopecia; acne is common in men with elevated total and free testosterone levels, and increased DHT exacerbates the problem.


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