神经生长因子(NGF)向大脑生物传递与阿尔茨海默病相关的技术综述。

PubMed ID
发表日期 2021年月

原始出处 实验医学与生物学进展
Advances in experimental medicine and biology
作者 Mitra  Sumonto  Gera  Ruchi  Linderoth  Bengt  Lind  Göran  Wahlberg  Lars  Almqvist  Per  Behbahani  Homira  Eriksdotter  Maria 

文献标题 神经生长因子(NGF)向大脑生物传递与阿尔茨海默病相关的技术综述。
A Review of Techniques for Biodelivery of Nerve Growth Factor (NGF) to the Brain in Relation to Alzheimer's Disease.

文献摘要

年龄依赖性进行性神经退行性变和相关的认知功能障碍是全世界严重关注的问题。目前,痴呆症占死亡原因的第五位,其中阿尔茨海默病(AD)占60%以上。AD与进行性认知功能障碍相关,影响患者和相关家庭的日常生活。认知功能障碍至少部分归因于一组特定神经元(胆碱能神经元)的退化,这些神经元的胞体位于基底前脑区(基底前脑胆碱能神经元,BFCNs),但支配大脑的广泛区域。已经明确表明,神经营养蛋白神经生长因子(NGF)的输送可以拯救BFCNs并恢复认知功能障碍,使NGF成为AD的潜在治疗物质。不幸的是,NGF不能通过血脑屏障(BBB),因此NGF蛋白的外周给药在治疗上不可行。NGF的传递方式必须能够使其大脑穿透并进入BFCN,从而调节BFCN的活性和生存能力。在过去的几十年中,已经开发了各种方法将NGF输送到脑组织。在本章中,将在AD的背景下讨论NGF的交付方法。


Age-dependent progressive neurodegeneration and associated cognitive dysfunction represent a serious concern worldwide. Currently, dementia accounts for the fifth highest cause of death, among which Alzheimer's disease (AD) represents more than 60% of the cases. AD is associated with progressive cognitive dysfunction which affects daily life of the affected individual and associated family. The cognitive dysfunctions are at least partially due to the degeneration of a specific set of neurons (cholinergic neurons) whose cell bodies are situated in the basal forebrain region (basal forebrain cholinergic neurons, BFCNs) but innervate wide areas of the brain. It has been explicitly shown that the delivery of the neurotrophic protein nerve growth factor (NGF) can rescue BFCNs and restore cognitive dysfunction, making NGF interesting as a potential therapeutic substance for AD. Unfortunately, NGF cannot pass through the blood-brain barrier (BBB) and thus peripheral administration of NGF protein is not viable therapeutically. NGF must be delivered in a way which will allow its brain penetration and availability to the BFCNs to modulate BFCN activity and viability. Over the past few decades, various methodologies have been developed to deliver NGF to the brain tissue. In this chapter, NGF delivery methods are discussed in the context of AD.


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