细纤维膜与水基乳液配合使用可改善干燥皮肤的功效。

干性皮肤会引发湿疹，影响超过10%的美国人口。敷料薄膜已被开发用于改善患病皮肤，但对其效果的了解有限，尤其是对于与皮肤干燥相关的症状。我们开发了一种静电纺丝方法，可以产生一种被称为细纤维（FF）膜的涂层，其特征是在皮肤表面生成一层透明、薄、柔韧且粘附的膜。

这项初步研究的目的是检查FF膜对干燥皮肤的影响。

设计了三种治疗方法（仅使用乳液、使用FF膜的乳液和使用替代膜的乳液）来治疗小腿皮肤粗糙的受试者。24名女性被纳入研究，使用水基洗剂U或矿脂基洗剂P和FF膜2周，然后进行1周的回归阶段。评估皮肤水合作用和粗糙度得分，以及受试者对效果的感知。

当FF膜与乳液U一起使用时，即使在1周后，皮肤水合作用也显著改善，伴随着皮肤粗糙度的显著改善和回归阶段结束时皮肤水合作用的增加。对水分渗透性的评估表明，FF膜，尤其是含有乳液U的FF膜，表现为半透膜，对干燥皮肤具有最佳的水分愈合效果。

FF膜和水基乳液是一种很有希望的治疗方法，可快速改善干燥皮肤状况。

Dry skin can trigger eczema that affects >10% of the US population. Dressing films have been developed to improve diseased skin, but there is limited knowledge about their effects, especially for dry skin-related symptoms. We developed an electrospinning method that creates a coating film, called a fine fiber (FF) film, characterized by the production of a transparent, thin, flexible, and adherent membrane on the skin surface.

The aim of this pilot study was to examine the effects of the FF film on dry skin.

Three treatments (lotion only, lotion with the FF film, and lotion with an alternative film) were designed to treat subjects with rough skin on their lower legs. Twenty-four females were enrolled and used either a water-based lotion U or a petrolatum-based lotion P and the FF film for 2 weeks followed by a regression phase for 1 week. Skin hydration and roughness scores were assessed as were the subjects' perceptions of the effects.

When the FF film was applied with lotion U, skin hydration was significantly improved even after 1 week, accompanied by a significant improvement of skin roughness and an increase in skin hydration by the end of the regression phase. An evaluation of moisture permeability suggested that the FF film, especially with lotion U, performed as a semipermeable membrane with optimal moisture healing effects on dry skin.

The FF film together with a water-based lotion is a promising treatment to quickly improve dry skin conditions.