聚维酮碘与其他防腐剂灭活人病毒的比较。

PubMed ID
发表日期 1997年月

原始出处 皮肤科(瑞士巴塞尔)
Dermatology (Basel, Switzerland)
作者 Kawana  R  Kitamura  T  Nakagomi  O  Matsumoto  I  Arita  M  Yoshihara  N  Yanagi  K  Yamada  A  Morita  O  Yoshida  Y  Furuya  Y  Chiba  S 

文献标题 聚维酮碘与其他防腐剂灭活人病毒的比较。
Inactivation of human viruses by povidone-iodine in comparison with other antiseptics.

文献摘要

根据标准化体外试验方案,研究了聚维酮碘(PVP-I)和其他市售防腐剂对一系列病毒的灭活作用,如腺病毒、腮腺炎病毒、罗塔病毒、脊髓灰质炎病毒(1型和3型)、柯萨奇病毒、犀牛病毒、单纯疱疹病毒、风疹病毒、麻疹病毒、流感病毒和人类免疫缺陷病毒。在这些实验中,使用了PVP-I溶液、PVP-I漱口液、PVP-I乳膏、葡萄糖酸氯己定、烷基二氨基乙基甘氨酸盐酸盐、苄扎溴铵(BAC)和苄乙溴铵(BEC)等防腐剂。PVP-I对所有被测病毒均有效。在这些实验中检测到的PVP-I药物在短时间内灭活了所有病毒。风疹、麻疹、流行性腮腺炎病毒和HIV对所有防腐剂均敏感,轮状病毒被BAC和BEC灭活,而腺病毒、脊髓灰质炎病毒和鼻病毒对其他抗菌药物无反应。PVP-I比其他市面上可买到的防腐剂具有更广泛的杀灭病毒谱,包括包膜病毒和非包膜病毒。


Inactivation of a range of viruses, such as adeno-, mumps, rota-, polio- (types 1 and 3), coxsackie-, rhino-, herpes simplex, rubella, measles, influenza and human immunodeficiency viruses, by povidone-iodine (PVP-I) and other commercially available antiseptics in Japan was studied in accordance with the standardized protocol in vitro. In these experiments, antiseptics such as PVP-I solution, PVP-I gargle, PVP-I cream, chlorhexidine gluconate, alkyldiaminoethyl-glycine hydrochloride, benzalkonium chloride (BAC) and benzethonium chloride (BEC) were used. PVP-I was effective against all the virus species tested. PVP-I drug products, which were examined in these experiments, inactivated all the viruses within a short period of time. Rubella, measles, mumps viruses and HIV were sensitive to all of the antiseptics, and rotavirus was inactivated by BAC and BEC, while adeno-, polio- and rhinoviruses did not respond to the other antiseptics. PVP-I had a wider virucidal spectrum, covering both enveloped and nonenveloped viruses, than the other commercially available antiseptics.


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