MIB-1(Ki-67)指数和转化生长因子-α(TGF-α)免疫反应性是脑膜瘤预后的重要预测指标。

PubMed ID
发表日期 1998年Dec月

原始出处 神经病理学与应用神经生物学
Neuropathology and applied neurobiology
作者 Hsu  D W  Efird  J T  Hedley-Whyte  E T 

文献标题 MIB-1(Ki-67)指数和转化生长因子-α(TGF-α)免疫反应性是脑膜瘤预后的重要预测指标。
MIB-1 (Ki-67) index and transforming growth factor-alpha (TGF alpha) immunoreactivity are significant prognostic predictors for meningiomas.

文献摘要

有丝分裂指数>6、增殖细胞核抗原(PCNA)指数>5%、肿瘤分级高和孕酮受体(PR)缺乏是脑膜瘤预后不良的重要预测因素。由于MIB-1(Ki-67)是一种更特异的细胞增殖标志物,TGF-α的过度表达也与肿瘤进展有关,我们将这些因素与其他指标的预后意义进行了比较。21名男性和36名女性(年龄54.5+/-1.7,平均+/-SEM)的颅内脑膜瘤被分为良性24例,非典型24例和恶性9例。57例肿瘤中有21例复发(平均复发间隔为57.3±13.1个月)。无肿瘤复发患者的平均随访期为81.9+/-8.7个月。MIB-1标记指数(LI)以标记核占标记最密集区域肿瘤细胞核总数的百分比表示。方差分析显示,MIB-1标记指数在肿瘤分级之间存在显著差异(良性为0.75+/-0.21,非典型为3.2+/-0.57,恶性为6.04+/-1.48;P<or=0.0066),恶性脑膜瘤和非恶性脑膜瘤的TGF-α染色评分之间存在显著差异(P<or=0.029)。MIB-1li也与有丝分裂指数和PCNA指数相关(P<or=0.0001),但与患者年龄无关。男性患者的肿瘤MIB-1 LI高于女性(P<or=0.0128)。单因素分析显示MIB-1li>3%,TGF-α评分>4(评分0-5),有丝分裂指数>6,PR阴性是预后不良的重要因素。高MIB-1li、TGF-α评分和有丝分裂指数作为连续变量也是显著的负预测因子。多变量分析显示,MIB-1li和TGF-alpha评分与所有其他变量(TGF-alpha或MIB-1li、有丝分裂、PCNA、肿瘤分级、PR状态、年龄、性别、术后放疗)配对后仍有显著性差异。结论MIB-1li和TGF-α评分是脑膜瘤患者重要的独立预后指标。


Mitotic index > 6, proliferating cell nuclear antigen (PCNA) index > 5%, high tumour grade and absence of progesterone receptors (PR) are significant predictors for poor outcome in meningiomas. Since MIB-1 (Ki-67) is a more specific cell proliferation marker, and overexpression of TGF-alpha is also associated with tumour progression, we compared the prognostic significance of these factors with the other indices. Intracranial meningiomas from 21 men and 36 women (age 54.5 +/- 1.7, mean +/- SEM) were classified as 24 benign, 24 atypical and nine malignant. Twenty-one of the 57 tumours recurred (mean interval to recurrence was 57.3 +/- 13.1 months). The mean follow-up period for patients without tumour recurrence was 81.9 +/- 8.7 months. MIB-1 labelling index (LI) was expressed as percentage of labelled nuclei to total tumour nuclei counted in the most densely labelled areas. Analysis of variance revealed significant differences between tumour grades for MIB-1 labelling indices (0.75 +/- 0.21 for benign, 3.2 +/- 0.57 for atypical 6.04 +/- 1.48 for malignant; P < or = 0.0066), and between malignant and non-malignant meningiomas for TGF alpha staining scores (P < or = 0.029). MIB-1 LI also correlated with mitotic and PCNA indices (P < or = 0.0001), but not with age of the patients. Male patients had higher tumour MIB-1 LI than females (P < or = 0.0128). Univariate analysis indicated that MIB-1 LI > 3%, TGF alpha score > 4 (scoring scale 0-5), mitotic index > 6, and negative PR status were significant factors for worse outcome. Higher MIB-1 LI, TGF alpha score and mitotic index as continuous variables were also significant negative predictors. With multivariate analysis, both MIB-1 LI and TGF alpha score remained significant factors when paired with all other variables: TGF alpha or MIB-1 LI, respectively, mitosis, PCNA, tumour grade, PR status, age, sex, postoperative radiation therapy. We conclude that MIB-1 LI and TGF alpha score are important independent prognostic indicators for patients with meningiomas.


获取全文 10.1046/j.1365-2990.1998.00150.x